Application | Comment | Organism |
---|---|---|
drug development | the bacterial enoyl-ACP reductase is a target for antibacterial drug development | Streptococcus pneumoniae |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
aquastatin A | a natural inhibitor from the fungus Sporothrix sp. strain FN611, prevents the growth of Staphylococcus pneumoniae with minimum inhibitory concentration of 0.064-0.128 mg/ml, overview | Streptococcus pneumoniae | |
degalactosylated aquastatin A | a natural inhibitor from the fungus Sporothrix sp. strain FN611 | Streptococcus pneumoniae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptococcus pneumoniae | - |
- |
- |
Streptococcus pneumoniae KCTC 3932 | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | activity measurement by reduction of the trans-2-octenoyl N-acetylcysteamine as substrate and NADH as cofactor | Streptococcus pneumoniae | ? | - |
? | |
additional information | activity measurement by reduction of the trans-2-octenoyl N-acetylcysteamine as substrate and NADH as cofactor | Streptococcus pneumoniae KCTC 3932 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
enoyl-ACP reductase | - |
Streptococcus pneumoniae |
enoyl-acyl carrier protein reductase | - |
Streptococcus pneumoniae |
FabK | - |
Streptococcus pneumoniae |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Streptococcus pneumoniae |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.5 | - |
assay at | Streptococcus pneumoniae |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | - |
Streptococcus pneumoniae |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0092 | - |
FabK, pH 6.5, 30°C | Streptococcus pneumoniae | aquastatin A | |
0.0106 | - |
FabI, pH 6.5, 30°C | Streptococcus pneumoniae | degalactosylated aquastatin A |