Literature summary for 1.3.1.89 extracted from

Xing, F.; Hiley, S.L.; Hughes, T.R.; Phizicky, E.M.
The specificities of four yeast dihydrouridine synthases for cytoplasmic tRNAs (2004), J. Biol. Chem., 279, 17850-17860.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
uracil47 in tRNA + NAD(P)H + H+	Saccharomyces cerevisiae	the enzyme specifically modifies uracil47 in tRNA, e.g. tRNATyr	5,6-dihydrouracil20 in tRNA + NAD(P)+	-	?

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	Q06053	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
uracil47 in tRNA + NAD(P)H + H+	the enzyme specifically modifies uracil47 in tRNA, e.g. tRNATyr	Saccharomyces cerevisiae	5,6-dihydrouracil20 in tRNA + NAD(P)+	-	?
uracil47 in tRNA + NAD(P)H + H+	e.g. tRNATyr	Saccharomyces cerevisiae	5,6-dihydrouracil47 in tRNA + NAD(P)+	-	?

Synonyms

Synonyms	Comment	Organism
Dus3p	-	Saccharomyces cerevisiae
tRNA-dihydrouridine synthase 3	-	Saccharomyces cerevisiae

General Information

General Information	Comment	Organism
physiological function	formation of dihydrouridine in yeast cytoplasmic tRNAs is carried out by a family of four dihydrouridine synthases (Dus1p, Dus2p, Dus3p, and Dus4p), each acting at specific positions in tRNAs. Dus1p modifies U16 and U17, Dus2p modifies U20, Dus3p modifies U47, and Dus4p modifies U20a and U20b. These four proteins are responsible for all dihydrouridine modification of cytoplasmic tRNAs in yeast	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)