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Literature summary for 1.3.1.72 extracted from

  • Pedretti, A.; Bocci, E.; Maggi, R.; Vistoli, G.
    Homology modelling of human DHCR24 (seladin-1) and analysis of its binding properties through molecular docking and dynamics simulations (2008), Steroids, 73, 708-719.
    View publication on PubMed
Search for more literature for 1.3.1.72

Protein Variants

Protein Variants Comment Organism
E191K decreased activity Homo sapiens
K306N decreased activity Homo sapiens
N294T decreased activity Homo sapiens
Y471S decreased activity Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane DHCR24 possesses a putative transmembrane segment Homo sapiens 16020
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q15392
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH
-
 Homo sapiens 4,4-dimethyl-5alpha-cholesta-8,14-dien-3beta-ol + NADP+
-
 ?
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADPH
-
 Homo sapiens 4,4-dimethyl-5alpha-cholesta-8-en-3beta-ol + NADP+
-
 ?
5alpha-cholesta-7,24-dien-3beta-ol + NADPH
-
 Homo sapiens 5alpha-cholest-7-en-3beta-ol + NADP+
-
 ?
7-dehydrodesmosterol + NADPH
-
 Homo sapiens 7-dehydrocholesterol + NADP+
-
 ?
desmosterol + FADH2
-
 Homo sapiens cholesterol + FAD + H+
-
 ?
lanosterol + NADPH + H+
-
 Homo sapiens 24-dihydrolanosterol + NADP+
-
 ?
zymosterol + NADPH
-
 Homo sapiens 5alpha-cholesta-8-en-3beta-ol + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
3-beta-hydroxysterol-DELTA24-reductase
-
 Homo sapiens
DHCR24 catalyzes the last step of the cholesterol biosynthesis Homo sapiens
seladin-1
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Homo sapiens