Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cholesterol | high levels of DHCR24 are associated with elevated cholesterol concentrations | Homo sapiens | |
H2O2 | DHCR24 mRNA levels increase in response to oxidative stress (0.1 mM H2O2) in a time-dependent manner, reaching the maximum after 4 h | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
N294T/K306N | mutant shows diminished activity | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
60000 | - |
SDS-PAGE | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Oxidation Stability | Organism |
---|---|
seladin-1 expression is up-regulated in an acute response and down-regulated in a chronic response to oxidative stress | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
SH-SY5Y cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
desmosterol + NADPH | - |
Homo sapiens | cholesterol + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
3beta-hydroxysterol-delta24 reductase | - |
Homo sapiens |
DHCR24 | - |
Homo sapiens |
seladin-1 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens |