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Literature summary for 1.3.1.72 extracted from

  • Giera, M.; Renard, D.; Ploessl, F.; Bracher, F.
    Lathosterol side chain amides—a new class of human lathosterol oxidase inhibitors (2008), Steroids, 73, 299-308.
    View publication on PubMed
Search for more literature for 1.3.1.72

Inhibitors

Inhibitors Comment Organism Structure
(2S)-2-((3S,5S,10S,13R,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-N-methylpropanamide 1 microM, 58% inhibition of total cholesterol production. Acts both on sterol reductoase and lathosterol oxidase Homo sapiens
(2S)-2-((3S,5S,10S,13R,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-N-propylpropanamide 1 microM, 45% inhibition of total cholesterol production. Acts both on sterol reductoase and lathosterol oxidase Homo sapiens
(2S)-2-((3S,5S,10S,13R,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)propanamide 1 microM, 75% inhibition of total cholesterol production Homo sapiens
(2S)-N-ethyl-2-((3S,5S,10S,13R,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)propanamide 1 microM, 61% inhibition of total cholesterol production Homo sapiens
(3S,5S,10S,13R,17R)-10,13-dimethyl-17-((S)-1-(methylamino)-1-oxopropan-2-yl)-2,3,4,5,6,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate 1 microM, 84% inhibition of total cholesterol production. Acts both on sterol reductoase and lathosterol oxidase Homo sapiens
(3S,5S,10S,13R,17R)-10,13-dimethyl-17-((S)-1-oxo-1-(propylamino)propan-2-yl)-2,3,4,5,6,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate 1 microM, 71% inhibition of total cholesterol production. Acts both on sterol reductoase and lathosterol oxidase Homo sapiens
(3S,5S,10S,13R,17R)-17-((S)-1-(ethylamino)-1-oxopropan-2-yl)-10,13-dimethyl-2,3,4,5,6,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate 1 microM, 97% inhibition of total cholesterol production Homo sapiens
(3S,5S,10S,13R,17R)-17-((S)-1-amino-1-oxopropan-2-yl)-10,13-dimethyl-2,3,4,5,6,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate 1 microM, 94% inhibition of total cholesterol production Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
HL-60 cell
-
 Homo sapiens
-