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Literature summary for 1.3.1.6 extracted from

  • Tomitsuka, E.; Kita, K.; Esumi, H.
    An anticancer agent, pyrvinium pamoate inhibits the NADH-fumarate reductase system - a unique mitochondrial energy metabolism in tumour microenvironments (2012), J. Biochem., 152, 171-183.
    View publication on PubMed
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Application

Application Comment Organism
medicine pyrvinium pamoate has an anti-cancer effect within tumour-mimicking microenvironments. Pyrvinium pamoate inhibits NADH-fumarate reductase activities in both parasites and mammalian mitochondria and increases the activity of complex II, succinate-ubiquinone reductase, which is part of fumarate reductase, in mitochondria from human cancer cells cultured under normoxia-normoglycemic conditions but not under hypoxia-hypoglycemic conditions Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
pyrvinium pamoate anthelmintic, has an anti-cancer effect within tumour-mimicking microenvironments. Pyrvinium pamoate inhibits NADH-fumarate reductase activities in both parasites and mammalian mitochondria and increases the activity of complex II, succinate-ubiquinone reductase, which is part of fumarate reductase, in mitochondria from human cancer cells cultured under normoxia-normoglycemic conditions but not under hypoxia-hypoglycemic conditions Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
DLD-1 cell under hypoxic-hypoglycemic conditions, NADH-fumarate reductase activity increases, whereas NADH-oxidase activity decreases Homo sapiens
-
Hep-G2 cell under hypoxic-hypoglycemic conditions, NADH-fumarate reductase activity increases, whereas NADH-oxidase activity decreases Homo sapiens
-
PANC-1 cell under hypoxic-hypoglycemic conditions, NADH-fumarate reductase activity increases, whereas NADH-oxidase activity decreases Homo sapiens
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0005
-
 pH 7.5, 30°C Homo sapiens pyrvinium pamoate