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Literature summary for 1.3.1.48 extracted from
- Purification and partial characterization of an NADH-linked delta13-15-ketoprostaglandin reductase from human placenta (1975), Biochem. Biophys. Res. Commun., 66, 541-546.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0548 | - |
NADH | - |
Homo sapiens |  |
| 0.07 | - |
15-ketoprostaglandin E2 | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| placenta | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.0405 | - |
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NAD(P)H | no substrates: 15-hydroxyprostaglandins, progesterone, cortisone, orotic acid, fumaric acid | Homo sapiens | (5Z)-11alpha-hydroxy-9,15-dioxoprost-5-enoate + NAD(P)+ | - |
? | |
| 11-hydroxy-9,15-dioxoprosta-5,13-dien-1-oic acid + NAD(P)H | i.e. 15-ketoprostaglandin E2 | Homo sapiens | 11-hydroxy-9,15-dioxoprosta-5-en-1-oic acid + NAD(P)+ | - |
? | |
| 15-ketoprostaglandin E2 + NADH + H+ | - |
Homo sapiens | 13,14-dihydro-15-ketoprostaglandin E2 + NAD+ | - |
r | |
| 9,11-dihydroxy-15-oxoprosta-5,13-dien-1-oic acid + NAD(P)H | i.e. 15-ketoprostaglandin F2alpha | Homo sapiens | 9,11-dihydroxy-15-oxoprosta-5-en-1-oic aicd + NAD(P)+ | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5.5 | - |
- |
Homo sapiens |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | 7.5 | spontaneous oxidation of NADH below pH 6.0 | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD(P)H | - |
Homo sapiens | |
| NADH | human placenta: enzyme can use only NADH | Homo sapiens | |
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