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Literature summary for 1.3.1.24 extracted from

  • Young, S.C.; Storm, M.V.; Speed, J.S.; Kelsen, S.; Tiller, C.V.; Vera, T.; Drummond, H.A.; Stec, D.E.
    Inhibition of biliverdin reductase increases angiotensin II-dependent superoxide levels in cultured renal tubular epithelial cells (2009), Am. J. Physiol. Regul. Integr. Comp. Physiol., 297, R1546-R1553.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
siRNA
-
Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
bilirubin + NAD(P)+ Mus musculus
-
biliverdin + NAD(P)H + H+
-
r

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
IMCD-3 cell
-
Mus musculus
-
TALH cell
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
bilirubin + NAD(P)+
-
Mus musculus biliverdin + NAD(P)H + H+
-
r

Synonyms

Synonyms Comment Organism
biliverdin reductase
-
Mus musculus
BVR
-
Mus musculus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Mus musculus

Expression

Organism Comment Expression
Mus musculus treatment of cultured TALH or IMCD-3 cells with BVR siRNA, 50 or 100 nM, results in an 80% decrease in the level of BVR protein down