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Literature summary for 1.3.1.24 extracted from

  • Lerner-Marmarosh, N.; Shen, J.; Torno, M.D.; Kravets, A.; Hu, Z.; Maines, M.D.
    Human biliverdin reductase: A member of the insulin receptor substrate family with serine/threonine/tyrosine kinase activity (2005), Proc. Natl. Acad. Sci. USA, 102, 7109-7114.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.3.1.24

Activating Compound

Activating Compound Comment Organism Structure
Insulin increases BVR tyrosine autophosphorylation Homo sapiens

Application

Application Comment Organism
additional information potential role in the insulin signaling pathway, BVR is both a substrate for insulin receptor tyrosine kinase activity and a kinase for serine phosphorylation of insulin receptor substrate 1 Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
into vector pcDNA3, transformed into Escherichia coli DH5alpha, pGEX-4T2/human BVR vector Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information point mutations of serine residues in the kinase domain of the enzyme inhibits phosphotransferase activity Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Ca2+ abolishes autophosphorylation of BVR Homo sapiens
Mg2+ abolishes autophosphorylation of BVR Homo sapiens
Zn2+ inhibitory to autophosphorylation of BVR, can not be overcome with Mn2+ Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ acitvates BVR tyrosine kinase activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
insulin receptor substrate-1 + NAD(P)H the serine residues are targets for BVR phosphorylation Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
BVR
-
 Homo sapiens