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Literature summary for 1.3.1.24 extracted from
- Kinetic properties and regulation of biliverdin reductase (1988), Arch. Biochem. Biophys., 263, 1-9.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| bilirubin | product inhibition | Rattus norvegicus |  |
| Iron-hematoporphyrin | competitive, acts as biliverdin-bilirubin analog | Rattus norvegicus | |
| NAD+ | product inhibition | Rattus norvegicus | |
| NADP+ | product inhibition | Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0069 | - |
Biliverdin | at pH 7 | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| biliverdin + NAD(P)H | - |
Rattus norvegicus | bilirubin + NAD(P)+ | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADH | - |
Rattus norvegicus | |
| NADPH | - |
Rattus norvegicus | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0019 | - |
NAD+ | at pH 7 | Rattus norvegicus | |
| 0.0098 | - |
bilirubin | at pH 7 | Rattus norvegicus | |
| 0.0454 | 0.583 | NADP+ | at pH 8.7 | Rattus norvegicus | |
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