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Literature summary for 1.3.1.22 extracted from

  • Arellano, Y.; Bratoeff, E.; Garrido, M.; Soriano, J.; Heuze, Y.; Cabeza, M.
    New ester derivatives of dehydroepiandrosterone as 5alpha-reductase inhibitors (2011), Steroids, 76, 1241-1246.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
3beta-(3'-oxapentanoyloxy)-androst-5-en-17-one good in vitro inhibitory activity, but compound does not bind to the androgen receptors Homo sapiens
3beta-acetoxyandrost-5-en-17-one good in vitro inhibitory activity, but compound does not bind to the androgen receptors Homo sapiens
3beta-hexanoyloxyandrost-5-en-17-one good in vitro inhibitory activity, but compound does not bind to the androgen receptors Homo sapiens
dehydroepiandrosterone good in vitro inhibitory activity, but compound does not bind to the androgen receptors Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
prostate
-
Homo sapiens
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000000002
-
pH 6.5, 37°C Homo sapiens 3beta-hexanoyloxyandrost-5-en-17-one
0.0000011
-
pH 6.5, 37°C Homo sapiens 3beta-(3'-oxapentanoyloxy)-androst-5-en-17-one
0.0000052
-
pH 6.5, 37°C Homo sapiens 3beta-acetoxyandrost-5-en-17-one
0.000025
-
pH 6.5, 37°C Homo sapiens dehydroepiandrosterone