Application | Comment | Organism |
---|---|---|
analysis | radiosubstrate in vitro incubation method for the determination of 5alpha-reductase type 1 activity using rat liver microsomes as an enzyme source | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(5'S)-17beta-(2-chlorophenyl-4,5-dihydrooxazol-5-yl)androst-5-en-3-one | - |
Rattus norvegicus | |
(5'S)-17beta-(4-bromophenyl-4,5-dihydrooxazol-5-yl)androst-5-en-3-one | - |
Rattus norvegicus | |
finasteride | - |
Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
type 1 enzyme | - |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000008 | - |
pH 7.3, 37°C | Rattus norvegicus | finasteride | |
0.00072 | - |
pH 7.3, 37°C | Rattus norvegicus | (5'S)-17beta-(2-chlorophenyl-4,5-dihydrooxazol-5-yl)androst-5-en-3-one | |
0.00105 | - |
pH 7.3, 37°C | Rattus norvegicus | (5'S)-17beta-(4-bromophenyl-4,5-dihydrooxazol-5-yl)androst-5-en-3-one |