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Literature summary for 1.3.1.22 extracted from

  • Cussenot, O.; Azzouzi, A.R.; Nicolaiew, N.; Mangin, P.; Cormier, L.; Fournier, G.; Valeri, A.; Cancel-Tassin, G.
    Low-activity V89L variant in SRD5A2 is associated with aggressive prostate cancer risk: an explanation for the adverse effects observed in chemoprevention trials using 5-alpha-reductase inhibitors (2007), Eur. Urol., 52, 1082-1087.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
V89L the mutant of low 5-alpha-reductase type 2 activity is associated with an increased risk of aggressive prostate cancer Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
prostate adenocarcinoma cell
-
Homo sapiens
-
prostate gland
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
testosterone + NADPH + H+
-
Homo sapiens 5alpha-dihydrotestosterone + NADP+ + H+
-
?

Synonyms

Synonyms Comment Organism
5-alpha-reductase type 2
-
Homo sapiens
5A2
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Homo sapiens