Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.3.1.22 extracted from

  • Thomas, L.N.; Lazier, C.B.; Gupta, R.; Norman, R.W.; Troyer, D.A.; OBrien, S.P.; Rittmaster, R.S.
    Differential alterations in 5alpha-reductase type 1 and type 2 levels during development and progression of prostate cancer (2005), Prostate, 63, 231-239.
    View publication on PubMed

Application

Application Comment Organism
medicine 5alphaR1 is increased and 5alphaR2 is decreased during development of prostate cancer, increased expression of both isozymes in recurrent and metastatic cancer, both isozymes may be important in the development and progression of prostate cancer Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
into pCMV7 and transfered to COS-1 cells Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
24000
-
5alphaR2, immunoblotting Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
prostate cancer cell tissues with benign prostatic hyperplasia, primary prostate cancer, prostatic intraepithelial neoplasia, primary prostate cancer treated with neoadjuvant androgen ablation, locally recurrent prostate cancer specimens, and prostate cancer metastases Homo sapiens
-

Synonyms

Synonyms Comment Organism
5a-reductase type 1
-
Homo sapiens
5a-reductase type 2
-
Homo sapiens
5alphaR1
-
Homo sapiens
5alphaR2
-
Homo sapiens