Activating Compound | Comment | Organism | Structure |
---|---|---|---|
dihydrotestosterone | significantly increases 5alpha-R1 mRNA and 5alpha-R2 mRNA expression in male rats | Rattus norvegicus |
Application | Comment | Organism |
---|---|---|
medicine | higher expression of 5alpha-R2, which is considered a masculinizing enzyme, in the female versus male central nervous system, sexual dimorphism in the regulation of 5alpha isozymes by dihydrotestosterone | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
dihydrotestosterone | significantly decreases 5alpha-R1 mRNA and 5alpha-R2 mRNA expression in female rats | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
central nervous system | - |
Rattus norvegicus | - |
prefrontal cortex | similar 5alpha-R1 mRNA expression in female and male rats, 5alpha-R2 mRNA expression significantly higher in females than in males | Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
5alpha-R1 | - |
Rattus norvegicus |
5alpha-R2 | - |
Rattus norvegicus |
steroid 5alpha-reductase | - |
Rattus norvegicus |
type 1 steroid 5alpha-reductase | - |
Rattus norvegicus |
type 2 steroid 5alpha-reductase | - |
Rattus norvegicus |