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Literature summary for 1.3.1.22 extracted from

  • Blohm, T.R.; Metcalf, B.W.; Laughlin, M.E.; Sjoerdsma, A.; Schatzman, G.L.
    Inhibition of testosterone 5alpha-reductase by a proposed enzyme-activated, active site-directed inhibitor (1980), Biochem. Biophys. Res. Commun., 95, 273-280.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
(5alpha,20-R)-4-Diazo-21-hydroxy-20-methylpregnan-3-one RMI18,341 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
prostate gland
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholest-4-en-3-one + NADPH
-
 Rattus norvegicus 5-alpha-cholestan-3-one + NADP+
-
 ?

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000035
-
 (5alpha,20-R)-4-Diazo-21-hydroxy-20-methylpregnan-3-one at 25°C formation of the reversible EI complex is not rate-limiting for enzyme inactivation, and this is expressed as saturation kinetics for the inhibition reaction Rattus norvegicus