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Literature summary for 1.3.1.20 extracted from
- Overexpression of dihydrodiol dehydrogenase as a prognostic marker in resected gastric cancer patients (2009), Digest. Dis. Sci., 54, 342-347.
Application
| Application | Comment | Organism |
|---|---|---|
| diagnostics | overexpression of dihydrodiol dehydrogenase as a prognostic marker in resected gastric cancer patients, patients with DDH overexpression have a significantly higher incidence of early tumor recurrence and distant metastasis | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Homo sapiens | 5737 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | the enzyme is a member of the aldo-keto reductase superfamily, which normally reduces polycyclic aromatic hydrocarbons in the liver, it plays an important role in detoxification | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adenocarcinoma cell | tumor from patients with gastric cancer | Homo sapiens | - |
| liver | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
DDH expression in resected gastric cancer specimens correlated with mortality | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the enzyme is a member of the aldo-keto reductase superfamily, which normally reduces polycyclic aromatic hydrocarbons in the liver, it plays an important role in detoxification | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DDH | - |
Homo sapiens |
| dihydrodiol dehydrogenase | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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