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Literature summary for 1.3.1.20 extracted from

  • Hara, A.; Matsuura, K.; Tamada, Y.; Sato, K.; Miyabe, Y.; Deyashiki, Y.; Ishida, N.
    Relationship of human liver dihydrodiol dehydrogenases to hepatic bile-acid-binding protein and an oxidoreductase of human colon cells (1996), Biochem. J., 313, 373-376.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.3.1.20

Cloned(Commentary)

Cloned (Comment) Organism
DD1, expression in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline DD1, recombinant DD1, but DD2 less sensitive Homo sapiens
1,7-phenanthroline DD1, recombinant DD1, but DD2 less sensitive Homo sapiens
chenodeoxycholic acid DD2 very sensitive, DD1 less sensitive, recombinant DD1 Homo sapiens
Flufenamic acid DD1, DD2, recombinant DD1 Homo sapiens
Hexestrol DD1, DD2, recombinant DD1 Homo sapiens
Ibuprofen very sensitive: DD2, less sensitive: DD1, recombinant DD1 Homo sapiens
indomethacin DD1, DD2, recombinant DD1 Homo sapiens
lithocholic acid DD2, DD1, recombinant DD1 Homo sapiens
Ursodeoxycholic acid very sensitiv: DD2, less sensitiv: DD1, recombinant DD1 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q04828 DD1, DD2
-

Purification (Commentary)

Purification (Comment) Organism
DD1, recombinant from Escherichia coli Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
11
-
 DD2 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-indan-1-ol + NADP+ recombinant DD1, DD1, DD2 Homo sapiens ?
-
 ?
(S)-tetralol + NADP+ DD1, DD2, recombinant DD1 Homo sapiens ?
-
 ?
5beta-androstan-3alpha,17beta-diol + NADP+ DD1, DD2, recombinant DD1 Homo sapiens 5beta-androstan-3,17-dione + NADPH
-
 ?
5beta-pregnan-3,20-diol + NADP+ DD1, DD2, recombinant DD1 Homo sapiens 5beta-pregnan-20-ol-3-one + NADPH
-
 ?
trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+ DD1, DD2, recombinant DD1 Homo sapiens catechol + NAD(P)H
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.0317
-
 trans-benzene dihydrodiol DD2 Homo sapiens
0.0533
-
 trans-benzene dihydrodiol DD1 Homo sapiens
0.145
-
 trans-benzene dihydrodiol recombinant DD1 Homo sapiens
0.158
-
 (S)-indan-1-ol DD2 Homo sapiens
0.167
-
 (S)-indan-1-ol DD1 Homo sapiens
0.417
-
 (S)-indan-1-ol DD1 recombinant Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADP+
-
 Homo sapiens
NADPH
-
 Homo sapiens