Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-hydroxyacetophenone | - |
Canis sp. | |
4-hydroxyacetophenone | - |
Macaca fuscata | |
4-hydroxyacetophenone | inhibits dihydrodiol and D-xylose dehydrogenase activity | Sus scrofa | |
isoascorbic acid | - |
Canis sp. | |
isoascorbic acid | - |
Macaca fuscata | |
isoascorbic acid | inhibits dihydrodiol and D-xylose dehydrogenase activity | Sus scrofa | |
KCl | increase in Km-value for D-xylose and NADP+ | Sus scrofa | |
MgCl2 | - |
Macaca fuscata | |
MgCl2 | increase in Km-value for D-xylose and NADP+ | Sus scrofa |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | Km for diverse sugars | Sus scrofa | |
additional information | - |
additional information | Km for diverse sugars | Oryctolagus cuniculus | |
additional information | - |
additional information | Km for diverse sugars | Macaca fuscata | |
additional information | - |
additional information | Km for diverse sugars | Canis sp. | |
0.8 | - |
D-xylose | - |
Sus scrofa | |
1.6 | - |
D-xylose | - |
Canis sp. | |
4.4 | - |
D-xylose | - |
Oryctolagus cuniculus | |
4.4 | - |
D-xylose | - |
Macaca fuscata | |
6.4 | - |
D-xylose | - |
Macaca fuscata | |
6.5 | - |
D-xylose | liver D-xylose dehydrogenase | Sus scrofa |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Canis sp. | - |
dog | - |
Homo sapiens | - |
- |
- |
Macaca fuscata | - |
japanese monkey | - |
Oryctolagus cuniculus | - |
rabbit | - |
Sus scrofa | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Macaca fuscata |
- |
Canis sp. |
co-purification of dihydrodiol and D-xylose dehydrogenase activities indicating that EC 1.1.1.179 and EC 1.3.1.20 are the same enzyme | Sus scrofa |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH + H+ | D-xylose dehydrogenase EC 1.1.1.179 and dihydrodiol dehydrogenase EC 1.3.1.20 both follow an ordered bi-bi mechanism and are thus considered the same enzyme | Sus scrofa |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
intestine | - |
Homo sapiens | - |
intestine | - |
Canis sp. | - |
kidney | - |
Macaca fuscata | - |
kidney | - |
Canis sp. | - |
lens | - |
Sus scrofa | - |
lens | - |
Oryctolagus cuniculus | - |
lens | - |
Canis sp. | - |
liver | - |
Homo sapiens | - |
liver | - |
Sus scrofa | - |
liver | - |
Macaca fuscata | - |
liver | - |
Canis sp. | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
substrate specificities for diverse sugars | Sus scrofa |
additional information | - |
substrate specificities for diverse sugars | Oryctolagus cuniculus |
additional information | - |
substrate specificities for diverse sugars | Macaca fuscata |
additional information | - |
substrate specificities for diverse sugars | Canis sp. |
0.011 | - |
extract, substrate naphthalene dihydrodiol | Sus scrofa |
0.024 | - |
extract, substrate naphthalene dihydrodiol | Macaca fuscata |
0.038 | - |
extract, substrate naphthalene dihydrodiol | Canis sp. |
7.3 | - |
co-purified enzyme, D-xylose dehydrogenase activity | Sus scrofa |
8 | - |
co-purified enzyme, dihydrodiol dehydrogenase activity | Sus scrofa |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-deoxy-D-glucose + NADP+ | low activity | Sus scrofa | 2-deoxy-D-glucono-1,5-lactone + NADPH + H+ | - |
? | |
2-deoxy-D-glucose + NADP+ | low activity | Oryctolagus cuniculus | 2-deoxy-D-glucono-1,5-lactone + NADPH + H+ | - |
? | |
2-deoxy-D-glucose + NADP+ | low activity | Macaca fuscata | 2-deoxy-D-glucono-1,5-lactone + NADPH + H+ | - |
? | |
2-deoxy-D-glucose + NADP+ | low activity | Canis sp. | 2-deoxy-D-glucono-1,5-lactone + NADPH + H+ | - |
? | |
D-arabinose + NADP+ | low activity | Sus scrofa | D-arabinono-1,4-lactone + NADPH | - |
? | |
D-arabinose + NADP+ | low activity | Oryctolagus cuniculus | D-arabinono-1,4-lactone + NADPH | - |
? | |
D-arabinose + NADP+ | low activity | Macaca fuscata | D-arabinono-1,4-lactone + NADPH | - |
? | |
D-arabinose + NADP+ | low activity | Canis sp. | D-arabinono-1,4-lactone + NADPH | - |
? | |
D-galactose + NADP+ | low activity | Sus scrofa | D-galactono-1,5-lactone + NADPH | - |
? | |
D-galactose + NADP+ | low activity | Oryctolagus cuniculus | D-galactono-1,5-lactone + NADPH | - |
? | |
D-galactose + NADP+ | low activity | Macaca fuscata | D-galactono-1,5-lactone + NADPH | - |
? | |
D-galactose + NADP+ | low activity | Canis sp. | D-galactono-1,5-lactone + NADPH | - |
? | |
D-glucose + NADP+ | low activity | Sus scrofa | D-glucono-1,5-lactone + NADPH + H+ | - |
? | |
D-glucose + NADP+ | low activity | Oryctolagus cuniculus | D-glucono-1,5-lactone + NADPH + H+ | - |
? | |
D-glucose + NADP+ | low activity | Macaca fuscata | D-glucono-1,5-lactone + NADPH + H+ | - |
? | |
D-glucose + NADP+ | low activity | Canis sp. | D-glucono-1,5-lactone + NADPH + H+ | - |
? | |
D-ribose + NADP+ | - |
Sus scrofa | ? | - |
? | |
D-ribose + NADP+ | - |
Oryctolagus cuniculus | ? | - |
? | |
D-ribose + NADP+ | - |
Macaca fuscata | ? | - |
? | |
D-ribose + NADP+ | - |
Canis sp. | ? | - |
? | |
D-xylose + NADP+ | also low activity with L-xylose | Sus scrofa | D-xylono-1,5-lactone + NADPH + H+ | - |
? | |
D-xylose + NADP+ | also low activity with L-xylose | Oryctolagus cuniculus | D-xylono-1,5-lactone + NADPH + H+ | - |
? | |
D-xylose + NADP+ | also low activity with L-xylose | Macaca fuscata | D-xylono-1,5-lactone + NADPH + H+ | - |
? | |
D-xylose + NADP+ | also low activity with L-xylose | Canis sp. | D-xylono-1,5-lactone + NADPH + H+ | - |
? | |
trans-naphthalene dihydrodiol + NAD(P)+ | - |
Homo sapiens | ? | - |
? | |
trans-naphthalene dihydrodiol + NAD(P)+ | - |
Sus scrofa | ? | - |
? | |
trans-naphthalene dihydrodiol + NAD(P)+ | - |
Oryctolagus cuniculus | ? | - |
? | |
trans-naphthalene dihydrodiol + NAD(P)+ | - |
Macaca fuscata | ? | - |
? | |
trans-naphthalene dihydrodiol + NAD(P)+ | - |
Canis sp. | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DD | - |
Homo sapiens |
DD | - |
Sus scrofa |
DD | - |
Oryctolagus cuniculus |
DD | - |
Macaca fuscata |
DD | - |
Canis sp. |
dihydrodiol dehydrogenase | - |
Homo sapiens |
dihydrodiol dehydrogenase | - |
Sus scrofa |
dihydrodiol dehydrogenase | - |
Oryctolagus cuniculus |
dihydrodiol dehydrogenase | - |
Macaca fuscata |
dihydrodiol dehydrogenase | - |
Canis sp. |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
- |
Homo sapiens |
25 | - |
assay at, substrates naphthalene dihydrodiol and NADP+ | Sus scrofa |
25 | - |
assay at, substrates naphthalene dihydrodiol and NADP+ | Macaca fuscata |
25 | - |
assay at, substrates naphthalene dihydrodiol and NADP+ | Canis sp. |
30 | - |
assay at, substrate D-xylose, pH 10.0 | Sus scrofa |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Homo sapiens | |
NADP+ | - |
Sus scrofa | |
NADP+ | - |
Oryctolagus cuniculus | |
NADP+ | - |
Macaca fuscata | |
NADP+ | - |
Canis sp. | |
NADPH | - |
Homo sapiens | |
NADPH | - |
Sus scrofa | |
NADPH | - |
Oryctolagus cuniculus | |
NADPH | - |
Macaca fuscata | |
NADPH | - |
Canis sp. |