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Literature summary for 1.3.1.20 extracted from

  • Aoki, S.; Ishikura, S.; Asada, Y.; Usami, N.; Hara, A.
    Identity of dimeric dihydrodiol dehydrogenase as NADP+-dependent D-xylose dehydrogenase in pig liver (2001), Chem. Biol. Interact., 130-132, 775-784.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
4-hydroxyacetophenone
-
Canis sp.
4-hydroxyacetophenone
-
Macaca fuscata
4-hydroxyacetophenone inhibits dihydrodiol and D-xylose dehydrogenase activity Sus scrofa
isoascorbic acid
-
Canis sp.
isoascorbic acid
-
Macaca fuscata
isoascorbic acid inhibits dihydrodiol and D-xylose dehydrogenase activity Sus scrofa
KCl increase in Km-value for D-xylose and NADP+ Sus scrofa
MgCl2
-
Macaca fuscata
MgCl2 increase in Km-value for D-xylose and NADP+ Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information Km for diverse sugars Sus scrofa
additional information
-
additional information Km for diverse sugars Oryctolagus cuniculus
additional information
-
additional information Km for diverse sugars Macaca fuscata
additional information
-
additional information Km for diverse sugars Canis sp.
0.8
-
D-xylose
-
Sus scrofa
1.6
-
D-xylose
-
Canis sp.
4.4
-
D-xylose
-
Oryctolagus cuniculus
4.4
-
D-xylose
-
Macaca fuscata
6.4
-
D-xylose
-
Macaca fuscata
6.5
-
D-xylose liver D-xylose dehydrogenase Sus scrofa

Organism

Organism UniProt Comment Textmining
Canis sp.
-
dog
-
Homo sapiens
-
-
-
Macaca fuscata
-
japanese monkey
-
Oryctolagus cuniculus
-
rabbit
-
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Macaca fuscata
-
Canis sp.
co-purification of dihydrodiol and D-xylose dehydrogenase activities indicating that EC 1.1.1.179 and EC 1.3.1.20 are the same enzyme Sus scrofa

Reaction

Reaction Comment Organism Reaction ID
trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH + H+ D-xylose dehydrogenase EC 1.1.1.179 and dihydrodiol dehydrogenase EC 1.3.1.20 both follow an ordered bi-bi mechanism and are thus considered the same enzyme Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
intestine
-
Homo sapiens
-
intestine
-
Canis sp.
-
kidney
-
Macaca fuscata
-
kidney
-
Canis sp.
-
lens
-
Sus scrofa
-
lens
-
Oryctolagus cuniculus
-
lens
-
Canis sp.
-
liver
-
Homo sapiens
-
liver
-
Sus scrofa
-
liver
-
Macaca fuscata
-
liver
-
Canis sp.
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
substrate specificities for diverse sugars Sus scrofa
additional information
-
substrate specificities for diverse sugars Oryctolagus cuniculus
additional information
-
substrate specificities for diverse sugars Macaca fuscata
additional information
-
substrate specificities for diverse sugars Canis sp.
0.011
-
extract, substrate naphthalene dihydrodiol Sus scrofa
0.024
-
extract, substrate naphthalene dihydrodiol Macaca fuscata
0.038
-
extract, substrate naphthalene dihydrodiol Canis sp.
7.3
-
co-purified enzyme, D-xylose dehydrogenase activity Sus scrofa
8
-
co-purified enzyme, dihydrodiol dehydrogenase activity Sus scrofa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-deoxy-D-glucose + NADP+ low activity Sus scrofa 2-deoxy-D-glucono-1,5-lactone + NADPH + H+
-
?
2-deoxy-D-glucose + NADP+ low activity Oryctolagus cuniculus 2-deoxy-D-glucono-1,5-lactone + NADPH + H+
-
?
2-deoxy-D-glucose + NADP+ low activity Macaca fuscata 2-deoxy-D-glucono-1,5-lactone + NADPH + H+
-
?
2-deoxy-D-glucose + NADP+ low activity Canis sp. 2-deoxy-D-glucono-1,5-lactone + NADPH + H+
-
?
D-arabinose + NADP+ low activity Sus scrofa D-arabinono-1,4-lactone + NADPH
-
?
D-arabinose + NADP+ low activity Oryctolagus cuniculus D-arabinono-1,4-lactone + NADPH
-
?
D-arabinose + NADP+ low activity Macaca fuscata D-arabinono-1,4-lactone + NADPH
-
?
D-arabinose + NADP+ low activity Canis sp. D-arabinono-1,4-lactone + NADPH
-
?
D-galactose + NADP+ low activity Sus scrofa D-galactono-1,5-lactone + NADPH
-
?
D-galactose + NADP+ low activity Oryctolagus cuniculus D-galactono-1,5-lactone + NADPH
-
?
D-galactose + NADP+ low activity Macaca fuscata D-galactono-1,5-lactone + NADPH
-
?
D-galactose + NADP+ low activity Canis sp. D-galactono-1,5-lactone + NADPH
-
?
D-glucose + NADP+ low activity Sus scrofa D-glucono-1,5-lactone + NADPH + H+
-
?
D-glucose + NADP+ low activity Oryctolagus cuniculus D-glucono-1,5-lactone + NADPH + H+
-
?
D-glucose + NADP+ low activity Macaca fuscata D-glucono-1,5-lactone + NADPH + H+
-
?
D-glucose + NADP+ low activity Canis sp. D-glucono-1,5-lactone + NADPH + H+
-
?
D-ribose + NADP+
-
Sus scrofa ?
-
?
D-ribose + NADP+
-
Oryctolagus cuniculus ?
-
?
D-ribose + NADP+
-
Macaca fuscata ?
-
?
D-ribose + NADP+
-
Canis sp. ?
-
?
D-xylose + NADP+ also low activity with L-xylose Sus scrofa D-xylono-1,5-lactone + NADPH + H+
-
?
D-xylose + NADP+ also low activity with L-xylose Oryctolagus cuniculus D-xylono-1,5-lactone + NADPH + H+
-
?
D-xylose + NADP+ also low activity with L-xylose Macaca fuscata D-xylono-1,5-lactone + NADPH + H+
-
?
D-xylose + NADP+ also low activity with L-xylose Canis sp. D-xylono-1,5-lactone + NADPH + H+
-
?
trans-naphthalene dihydrodiol + NAD(P)+
-
Homo sapiens ?
-
?
trans-naphthalene dihydrodiol + NAD(P)+
-
Sus scrofa ?
-
?
trans-naphthalene dihydrodiol + NAD(P)+
-
Oryctolagus cuniculus ?
-
?
trans-naphthalene dihydrodiol + NAD(P)+
-
Macaca fuscata ?
-
?
trans-naphthalene dihydrodiol + NAD(P)+
-
Canis sp. ?
-
?

Synonyms

Synonyms Comment Organism
DD
-
Homo sapiens
DD
-
Sus scrofa
DD
-
Oryctolagus cuniculus
DD
-
Macaca fuscata
DD
-
Canis sp.
dihydrodiol dehydrogenase
-
Homo sapiens
dihydrodiol dehydrogenase
-
Sus scrofa
dihydrodiol dehydrogenase
-
Oryctolagus cuniculus
dihydrodiol dehydrogenase
-
Macaca fuscata
dihydrodiol dehydrogenase
-
Canis sp.

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
-
Homo sapiens
25
-
assay at, substrates naphthalene dihydrodiol and NADP+ Sus scrofa
25
-
assay at, substrates naphthalene dihydrodiol and NADP+ Macaca fuscata
25
-
assay at, substrates naphthalene dihydrodiol and NADP+ Canis sp.
30
-
assay at, substrate D-xylose, pH 10.0 Sus scrofa

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Homo sapiens
NADP+
-
Sus scrofa
NADP+
-
Oryctolagus cuniculus
NADP+
-
Macaca fuscata
NADP+
-
Canis sp.
NADPH
-
Homo sapiens
NADPH
-
Sus scrofa
NADPH
-
Oryctolagus cuniculus
NADPH
-
Macaca fuscata
NADPH
-
Canis sp.