Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Sus scrofa |
Crystallization (Comment) | Organism |
---|---|
crystals diffract to 1.9 A | Sus scrofa |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,6-Dihydroxypyridine | competitive vs. uracil | Sus scrofa | |
5-Ethynyluracil | mechanism-based inhibition | Bos taurus | |
5-Iodo-uracil | mechanism-based inhibition | Bos taurus | |
5-Iodo-uracil | mechanism-based inactivator | Sus scrofa |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
cytosol | - |
Rattus norvegicus | 5829 | - |
cytosol | - |
Sus scrofa | 5829 | - |
cytosol | - |
Bos taurus | 5829 | - |
cytosol | - |
Cupriavidus necator | 5829 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Iron | each subunit contains 16 nonheme-irons in 4 [4Fe-4S] clusters | Sus scrofa |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
220000 | - |
- |
Sus scrofa |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,6-dihydrouracil + NADP+ | Homo sapiens | first and rate-limiting enzyme in the three-step pathway for the degradation of uracil | uracil + NADPH | - |
? | |
5,6-dihydrouracil + NADP+ | Rattus norvegicus | first and rate-limiting enzyme in the three-step pathway for the degradation of uracil | uracil + NADPH | - |
? | |
5,6-dihydrouracil + NADP+ | Sus scrofa | first and rate-limiting enzyme in the three-step pathway for the degradation of uracil | uracil + NADPH | - |
? | |
5,6-dihydrouracil + NADP+ | Bos taurus | first and rate-limiting enzyme in the three-step pathway for the degradation of uracil | uracil + NADPH | - |
? | |
5,6-dihydrouracil + NADP+ | Cupriavidus necator | first and rate-limiting enzyme in the three-step pathway for the degradation of uracil | uracil + NADPH | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Cupriavidus necator | - |
- |
- |
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Sus scrofa | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
- |
Rattus norvegicus |
- |
Sus scrofa |
- |
Bos taurus |
- |
Cupriavidus necator |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
liver | - |
Sus scrofa | - |
liver | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,6-dihydrouracil + NADP+ | - |
Homo sapiens | uracil + NADPH | - |
? | |
5,6-dihydrouracil + NADP+ | - |
Rattus norvegicus | uracil + NADPH | - |
? | |
5,6-dihydrouracil + NADP+ | - |
Sus scrofa | uracil + NADPH | - |
? | |
5,6-dihydrouracil + NADP+ | - |
Bos taurus | uracil + NADPH | - |
? | |
5,6-dihydrouracil + NADP+ | - |
Cupriavidus necator | uracil + NADPH | - |
? | |
5,6-dihydrouracil + NADP+ | first and rate-limiting enzyme in the three-step pathway for the degradation of uracil | Homo sapiens | uracil + NADPH | - |
? | |
5,6-dihydrouracil + NADP+ | first and rate-limiting enzyme in the three-step pathway for the degradation of uracil | Rattus norvegicus | uracil + NADPH | - |
? | |
5,6-dihydrouracil + NADP+ | first and rate-limiting enzyme in the three-step pathway for the degradation of uracil | Sus scrofa | uracil + NADPH | - |
? | |
5,6-dihydrouracil + NADP+ | first and rate-limiting enzyme in the three-step pathway for the degradation of uracil | Bos taurus | uracil + NADPH | - |
? | |
5,6-dihydrouracil + NADP+ | first and rate-limiting enzyme in the three-step pathway for the degradation of uracil | Cupriavidus necator | uracil + NADPH | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | - |
Sus scrofa |
Synonyms | Comment | Organism |
---|---|---|
DPD | - |
Homo sapiens |
DPD | - |
Rattus norvegicus |
DPD | - |
Sus scrofa |
DPD | - |
Bos taurus |
DPD | - |
Cupriavidus necator |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | 1 FAD per subunit | Sus scrofa | |
FMN | 1 FMN per subunit | Sus scrofa | |
NADP+ | - |
Homo sapiens | |
NADP+ | - |
Rattus norvegicus | |
NADP+ | - |
Sus scrofa | |
NADP+ | - |
Bos taurus | |
NADP+ | - |
Cupriavidus necator |