Protein Variants | Comment | Organism |
---|---|---|
additional information | PCR and sequence analysis of point mutations occurring in patients, modified cofactor binding and electron transport with exchanges: S201R, P86L, S492L, D949V, H978R, reduced activity in mutants | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-fluorouracil + NADPH + H+ | Homo sapiens | - |
5-fluoro-5,6-dihydrouracil + NADP+ | - |
? | |
thymine + NADPH | Homo sapiens | - |
dihydrothymine + NADP+ | - |
? | |
uracil + NADPH | Homo sapiens | rate limiting enzyme in pyrimidine degradation | 5,6-dihydrouracil + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-fluorouracil + NADPH + H+ | - |
Homo sapiens | 5-fluoro-5,6-dihydrouracil + NADP+ | - |
? | |
thymine + NADPH | - |
Homo sapiens | dihydrothymine + NADP+ | - |
? | |
uracil + NADPH | rate limiting enzyme in pyrimidine degradation | Homo sapiens | 5,6-dihydrouracil + NADP+ | - |
? |