Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.3.1.2 extracted from

  • Van Kuilenburg, A.B.P.; Van Lenthe, H.; Wanders, R.J.A.; Van Gennip, A.H.
    Subcellular localization of dihydropyrimidine dehydrogenase (1997), Biol. Chem., 378, 1047-1053.
    View publication on PubMed
Search for more literature for 1.3.1.2

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm exclusively Rattus norvegicus 5737
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
thymine + NADPH Rattus norvegicus
-
 dihydrothymine + NADP+
-
 r
uracil + NADPH Rattus norvegicus rate limiting step in catabolic breakdown of uracil to beta-alanine 5,6-dihydrouracil + NADP+
-
 r
uracil + NADPH Rattus norvegicus rate limiting enzyme in pyrimidine degradation 5,6-dihydrouracil + NADP+
-
 r

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,6-dihydrouracil + NADP+
-
 Rattus norvegicus uracil + NADPH
-
 ?
dihydrothymine + NADP+
-
 Rattus norvegicus thymine + NADPH
-
 r
thymine + NADPH
-
 Rattus norvegicus dihydrothymine + NADP+
-
 r
uracil + NADPH
-
 Rattus norvegicus 5,6-dihydrouracil + NADP+
-
 r
uracil + NADPH rate limiting step in catabolic breakdown of uracil to beta-alanine Rattus norvegicus 5,6-dihydrouracil + NADP+
-
 r
uracil + NADPH rate limiting enzyme in pyrimidine degradation Rattus norvegicus 5,6-dihydrouracil + NADP+
-
 r

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Rattus norvegicus