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Literature summary for 1.3.1.2 extracted from

  • Lu, Z.H.; Zhang, R.; Diasio, R.B.
    Comparison of dihydropyrimidine dehydrogenase from human, rat, pig and cow liver. Biochemical and immunological properties (1993), Biochem. Pharmacol., 46, 945-952.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0011
-
5-fluorouracil
-
Sus scrofa
0.0018
-
5-fluorouracil
-
Bos taurus
0.0024
-
Uracil
-
Rattus norvegicus
0.0026
-
thymine
-
Rattus norvegicus
0.0033
-
5-fluorouracil
-
Homo sapiens
0.0039
-
Uracil
-
Bos taurus
0.0046
-
thymine
-
Bos taurus
0.0048
-
thymine
-
Homo sapiens
0.0049
-
Uracil
-
Homo sapiens
0.0059
-
Uracil
-
Sus scrofa
0.0068
-
thymine
-
Sus scrofa
0.0082
-
NADPH in presence of 5-fluorouracil Sus scrofa
0.0085
-
NADPH in presence of 5-fluorouracil Bos taurus
0.0089
-
5-fluorouracil
-
Rattus norvegicus
0.0089
-
NADPH in presence of uracil Bos taurus
0.0096
-
NADPH in presence of uracil Homo sapiens
0.01
-
NADPH in presence of 5-fluorouracil Homo sapiens
0.0119
-
NADPH in presence of uracil Sus scrofa
0.0158
-
NADPH in presence of thymine Homo sapiens
0.0167
-
NADPH in presence of thymine Sus scrofa
0.0206
-
NADPH in presence of uracil Rattus norvegicus
0.0209
-
NADPH in presence of 5-fluorouracil Rattus norvegicus
0.0289
-
NADPH in presence of thymine Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Homo sapiens 5737
-
cytoplasm
-
Rattus norvegicus 5737
-
cytoplasm
-
Sus scrofa 5737
-
cytoplasm
-
Bos taurus 5737
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
102000
-
2 * 102000, SDS-PAGE Sus scrofa
105000
-
2 * 105000, SDS-PAGE Homo sapiens
105000
-
2 * 105000, SDS-PAGE Rattus norvegicus
108000
-
2 * 108000, SDS-PAGE Bos taurus
204000
-
HPLC gel filtration Sus scrofa
210000
-
gel filtration Homo sapiens
210000
-
gel filtration Rattus norvegicus
216000
-
gel filtration Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
thymine + NADPH Rattus norvegicus
-
dihydrothymine + NADP+
-
?
thymine + NADPH Sus scrofa
-
dihydrothymine + NADP+
-
?
thymine + NADPH Homo sapiens rate-limiting enzyme in catabolic detoxification of exogenous fluoropyrimidines dihydrothymine + NADP+
-
?
thymine + NADPH Bos taurus rate-limiting enzyme in catabolic detoxification of exogenous fluoropyrimidines dihydrothymine + NADP+
-
?
uracil + NADPH Homo sapiens rate limiting enzyme in pyrimidine degradation 5,6-dihydrouracil + NADP+
-
?
uracil + NADPH Rattus norvegicus rate limiting enzyme in pyrimidine degradation 5,6-dihydrouracil + NADP+
-
?
uracil + NADPH Sus scrofa rate limiting enzyme in pyrimidine degradation 5,6-dihydrouracil + NADP+
-
?
uracil + NADPH Bos taurus rate limiting enzyme in pyrimidine degradation 5,6-dihydrouracil + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens
-
Rattus norvegicus
-
Sus scrofa
-
Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-
liver
-
Rattus norvegicus
-
liver
-
Sus scrofa
-
liver
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-fluorouracil + NADPH + H+
-
Homo sapiens 5-fluoro-5,6-dihydrouracil + NADP+
-
?
5-fluorouracil + NADPH + H+
-
Rattus norvegicus 5-fluoro-5,6-dihydrouracil + NADP+
-
?
5-fluorouracil + NADPH + H+
-
Sus scrofa 5-fluoro-5,6-dihydrouracil + NADP+
-
?
5-fluorouracil + NADPH + H+
-
Bos taurus 5-fluoro-5,6-dihydrouracil + NADP+
-
?
dihydrothymine + NADP+
-
Homo sapiens thymine + NADPH
-
r
dihydrothymine + NADP+
-
Rattus norvegicus thymine + NADPH
-
r
dihydrothymine + NADP+
-
Sus scrofa thymine + NADPH
-
r
dihydrothymine + NADP+
-
Bos taurus thymine + NADPH
-
r
thymine + NADPH
-
Homo sapiens dihydrothymine + NADP+
-
?
thymine + NADPH
-
Rattus norvegicus dihydrothymine + NADP+
-
?
thymine + NADPH
-
Sus scrofa dihydrothymine + NADP+
-
?
thymine + NADPH
-
Bos taurus dihydrothymine + NADP+
-
?
thymine + NADPH rate-limiting enzyme in catabolic detoxification of exogenous fluoropyrimidines Homo sapiens dihydrothymine + NADP+
-
?
thymine + NADPH rate-limiting enzyme in catabolic detoxification of exogenous fluoropyrimidines Bos taurus dihydrothymine + NADP+
-
?
uracil + NADPH
-
Homo sapiens 5,6-dihydrouracil + NADP+
-
?
uracil + NADPH
-
Rattus norvegicus 5,6-dihydrouracil + NADP+
-
?
uracil + NADPH
-
Sus scrofa 5,6-dihydrouracil + NADP+
-
?
uracil + NADPH
-
Bos taurus 5,6-dihydrouracil + NADP+
-
?
uracil + NADPH rate limiting enzyme in pyrimidine degradation Homo sapiens 5,6-dihydrouracil + NADP+
-
?
uracil + NADPH rate limiting enzyme in pyrimidine degradation Rattus norvegicus 5,6-dihydrouracil + NADP+
-
?
uracil + NADPH rate limiting enzyme in pyrimidine degradation Sus scrofa 5,6-dihydrouracil + NADP+
-
?
uracil + NADPH rate limiting enzyme in pyrimidine degradation Bos taurus 5,6-dihydrouracil + NADP+
-
?

Subunits

Subunits Comment Organism
dimer 2 * 105000, SDS-PAGE Homo sapiens
dimer 2 * 105000, SDS-PAGE Rattus norvegicus
dimer 2 * 108000, SDS-PAGE Bos taurus
dimer 2 * 102000, SDS-PAGE Sus scrofa

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Homo sapiens
NADPH
-
Rattus norvegicus
NADPH
-
Sus scrofa
NADPH
-
Bos taurus