KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0011 | - |
5-fluorouracil | - |
Sus scrofa | |
0.0018 | - |
5-fluorouracil | - |
Bos taurus | |
0.0024 | - |
Uracil | - |
Rattus norvegicus | |
0.0026 | - |
thymine | - |
Rattus norvegicus | |
0.0033 | - |
5-fluorouracil | - |
Homo sapiens | |
0.0039 | - |
Uracil | - |
Bos taurus | |
0.0046 | - |
thymine | - |
Bos taurus | |
0.0048 | - |
thymine | - |
Homo sapiens | |
0.0049 | - |
Uracil | - |
Homo sapiens | |
0.0059 | - |
Uracil | - |
Sus scrofa | |
0.0068 | - |
thymine | - |
Sus scrofa | |
0.0082 | - |
NADPH | in presence of 5-fluorouracil | Sus scrofa | |
0.0085 | - |
NADPH | in presence of 5-fluorouracil | Bos taurus | |
0.0089 | - |
5-fluorouracil | - |
Rattus norvegicus | |
0.0089 | - |
NADPH | in presence of uracil | Bos taurus | |
0.0096 | - |
NADPH | in presence of uracil | Homo sapiens | |
0.01 | - |
NADPH | in presence of 5-fluorouracil | Homo sapiens | |
0.0119 | - |
NADPH | in presence of uracil | Sus scrofa | |
0.0158 | - |
NADPH | in presence of thymine | Homo sapiens | |
0.0167 | - |
NADPH | in presence of thymine | Sus scrofa | |
0.0206 | - |
NADPH | in presence of uracil | Rattus norvegicus | |
0.0209 | - |
NADPH | in presence of 5-fluorouracil | Rattus norvegicus | |
0.0289 | - |
NADPH | in presence of thymine | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
cytoplasm | - |
Rattus norvegicus | 5737 | - |
cytoplasm | - |
Sus scrofa | 5737 | - |
cytoplasm | - |
Bos taurus | 5737 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
102000 | - |
2 * 102000, SDS-PAGE | Sus scrofa |
105000 | - |
2 * 105000, SDS-PAGE | Homo sapiens |
105000 | - |
2 * 105000, SDS-PAGE | Rattus norvegicus |
108000 | - |
2 * 108000, SDS-PAGE | Bos taurus |
204000 | - |
HPLC gel filtration | Sus scrofa |
210000 | - |
gel filtration | Homo sapiens |
210000 | - |
gel filtration | Rattus norvegicus |
216000 | - |
gel filtration | Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
thymine + NADPH | Rattus norvegicus | - |
dihydrothymine + NADP+ | - |
? | |
thymine + NADPH | Sus scrofa | - |
dihydrothymine + NADP+ | - |
? | |
thymine + NADPH | Homo sapiens | rate-limiting enzyme in catabolic detoxification of exogenous fluoropyrimidines | dihydrothymine + NADP+ | - |
? | |
thymine + NADPH | Bos taurus | rate-limiting enzyme in catabolic detoxification of exogenous fluoropyrimidines | dihydrothymine + NADP+ | - |
? | |
uracil + NADPH | Homo sapiens | rate limiting enzyme in pyrimidine degradation | 5,6-dihydrouracil + NADP+ | - |
? | |
uracil + NADPH | Rattus norvegicus | rate limiting enzyme in pyrimidine degradation | 5,6-dihydrouracil + NADP+ | - |
? | |
uracil + NADPH | Sus scrofa | rate limiting enzyme in pyrimidine degradation | 5,6-dihydrouracil + NADP+ | - |
? | |
uracil + NADPH | Bos taurus | rate limiting enzyme in pyrimidine degradation | 5,6-dihydrouracil + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Sus scrofa | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
- |
Rattus norvegicus |
- |
Sus scrofa |
- |
Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
liver | - |
Sus scrofa | - |
liver | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-fluorouracil + NADPH + H+ | - |
Homo sapiens | 5-fluoro-5,6-dihydrouracil + NADP+ | - |
? | |
5-fluorouracil + NADPH + H+ | - |
Rattus norvegicus | 5-fluoro-5,6-dihydrouracil + NADP+ | - |
? | |
5-fluorouracil + NADPH + H+ | - |
Sus scrofa | 5-fluoro-5,6-dihydrouracil + NADP+ | - |
? | |
5-fluorouracil + NADPH + H+ | - |
Bos taurus | 5-fluoro-5,6-dihydrouracil + NADP+ | - |
? | |
dihydrothymine + NADP+ | - |
Homo sapiens | thymine + NADPH | - |
r | |
dihydrothymine + NADP+ | - |
Rattus norvegicus | thymine + NADPH | - |
r | |
dihydrothymine + NADP+ | - |
Sus scrofa | thymine + NADPH | - |
r | |
dihydrothymine + NADP+ | - |
Bos taurus | thymine + NADPH | - |
r | |
thymine + NADPH | - |
Homo sapiens | dihydrothymine + NADP+ | - |
? | |
thymine + NADPH | - |
Rattus norvegicus | dihydrothymine + NADP+ | - |
? | |
thymine + NADPH | - |
Sus scrofa | dihydrothymine + NADP+ | - |
? | |
thymine + NADPH | - |
Bos taurus | dihydrothymine + NADP+ | - |
? | |
thymine + NADPH | rate-limiting enzyme in catabolic detoxification of exogenous fluoropyrimidines | Homo sapiens | dihydrothymine + NADP+ | - |
? | |
thymine + NADPH | rate-limiting enzyme in catabolic detoxification of exogenous fluoropyrimidines | Bos taurus | dihydrothymine + NADP+ | - |
? | |
uracil + NADPH | - |
Homo sapiens | 5,6-dihydrouracil + NADP+ | - |
? | |
uracil + NADPH | - |
Rattus norvegicus | 5,6-dihydrouracil + NADP+ | - |
? | |
uracil + NADPH | - |
Sus scrofa | 5,6-dihydrouracil + NADP+ | - |
? | |
uracil + NADPH | - |
Bos taurus | 5,6-dihydrouracil + NADP+ | - |
? | |
uracil + NADPH | rate limiting enzyme in pyrimidine degradation | Homo sapiens | 5,6-dihydrouracil + NADP+ | - |
? | |
uracil + NADPH | rate limiting enzyme in pyrimidine degradation | Rattus norvegicus | 5,6-dihydrouracil + NADP+ | - |
? | |
uracil + NADPH | rate limiting enzyme in pyrimidine degradation | Sus scrofa | 5,6-dihydrouracil + NADP+ | - |
? | |
uracil + NADPH | rate limiting enzyme in pyrimidine degradation | Bos taurus | 5,6-dihydrouracil + NADP+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 105000, SDS-PAGE | Homo sapiens |
dimer | 2 * 105000, SDS-PAGE | Rattus norvegicus |
dimer | 2 * 108000, SDS-PAGE | Bos taurus |
dimer | 2 * 102000, SDS-PAGE | Sus scrofa |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens | |
NADPH | - |
Rattus norvegicus | |
NADPH | - |
Sus scrofa | |
NADPH | - |
Bos taurus |