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Literature summary for 1.3.1.2 extracted from

  • Podschun, B.; Cook, P.F.; Schnackerz, K.D.
    Kinetic mechanism of dihydropyrimidine dehydrogenase from pig liver (1990), J. Biol. Chem., 265, 12966-12972.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
5,6-Dihydropyrimidine
-
Sus scrofa
NADPH
-
Sus scrofa
Uracil
-
Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.001
-
Uracil
-
Sus scrofa
0.007
-
NADPH
-
Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
thymine + NADPH Sus scrofa
-
dihydrothymine + NADP+
-
?
uracil + NADPH Sus scrofa
-
5,6-dihydrouracil + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Reaction

Reaction Comment Organism Reaction ID
5,6-dihydrouracil + NADP+ = uracil + NADPH + H+ nonclassical ping-pong mechanism Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
thymine + NADPH
-
Sus scrofa dihydrothymine + NADP+
-
?
uracil + NADPH
-
Sus scrofa 5,6-dihydrouracil + NADP+
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Sus scrofa

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Sus scrofa
NADPH
-
Sus scrofa

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information inhibitory reactions between uracil, NADP+ and dihydrouracil Sus scrofa