Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Mus musculus | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q9CQ62 | - |
- |
Mus musculus | Q9CQ62 | isoform Decr1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brown adipose tissue | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
2,4-dienoyl-CoA reductase | - |
Mus musculus |
DECR | - |
Mus musculus |
DECR1 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | cold intolerance of Decr-/- mice is due to failure in maintaining appropriate heat production at least partly due to failure of brown adipose tissue (BAT) thermogenesis | Mus musculus |
metabolism | key enzyme required for beta-oxidation of polyunsaturated fatty acids | Mus musculus |
physiological function | cold intolerance of Decr?/? mice is due to failure in maintaining appropriate heat production at least partly due to failure of brown adipose tissue thermogenesis. Activation of lipolysis is attenuated despite of functional norepinephrine-signaling and inappropriate expression of genes contributing to thermogenesis in interscapular brown adipose rissue when the Decr?/? mice are exposed to cold | Mus musculus |