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Literature summary for 1.3.1.12 extracted from

  • Ahmad, S.; Jensen, R.A.
    Evolution of the biochemical pathway for aromatic amino acid biosynthesis in Serpens flexibilis in relationship to its phylogenetic position (1987), Arch. Microbiol., 147, 8-12.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
4-hydroxymercuribenzoate
-
Pseudomonas flexibilis
L-tyrosine
-
Pseudomonas flexibilis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.045 0.09 prephenate
-
Pseudomonas flexibilis
0.45
-
NAD+
-
Pseudomonas flexibilis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
prephenate + NAD+ Pseudomonas flexibilis biosynthesis of L-tyrosine 4-hydroxyphenylpyruvate + NADH + CO2
-
?

Organism

Organism UniProt Comment Textmining
Pseudomonas flexibilis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
copurification with arogenate dehydrogenase Pseudomonas flexibilis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
prephenate + NAD+
-
Pseudomonas flexibilis 4-hydroxyphenylpyruvate + NADH + CO2
-
?
prephenate + NAD+ biosynthesis of L-tyrosine Pseudomonas flexibilis 4-hydroxyphenylpyruvate + NADH + CO2
-
?

Cofactor

Cofactor Comment Organism Structure
additional information NADP+ cannot substitute for NAD+ Pseudomonas flexibilis
NAD+
-
Pseudomonas flexibilis

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.017
-
L-tyrosine with prephenate as variable substrate Pseudomonas flexibilis
0.02
-
L-tyrosine with NAD+ as variable substrate Pseudomonas flexibilis