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Literature summary for 1.3.1.1 extracted from

  • Sulzyc-Bielicka, V.; Binczak-Kuleta, A.; Pioch, W.; Kladny, J.; Gziut, K.; Bielicki, D.; Ciechanowicz, A.
    5-Fluorouracil toxicity-attributable IVS14+1G>A mutation of the dihydropyrimidine dehydrogenase gene in Polish colorectal cancer patients (2008), Pharmacol. Rep., 60, 238-242.
    View publication on PubMed
Search for more literature for 1.3.1.1

Protein Variants

Protein Variants Comment Organism
additional information mutation IVS14+1G>A results in a 165bp deletion (corresponding to exon 14) in the DPD mRNA, the resulting protein product is truncated by 55 amino acids, and its catalytic activity is virtually absent, the mutation is responsible for a significant proportion of life-threatening toxicity of 5-fluorouracil Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colorectal cancer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-fluorouracil + NADH + H+ dihydropyrimidine dehydrogenase is the initial and rate-limiting enzyme in the catabolism of 5-fluorouracil Homo sapiens 5-fluoro-5,6-dihydrouracil + NAD+
-
 ?

Synonyms

Synonyms Comment Organism
dihydropyrimidine dehydrogenase
-
 Homo sapiens
DPD
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Homo sapiens