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Literature summary for 1.3.1.1 extracted from

  • Jiang, H.; Jiang, J.; Hu, P.; Hu, Y.
    Measurement of endogenous uracil and dihydrouracil in plasma and urine of normal subjects by liquid chromatography-tandem mass spectrometry (2002), J. Chromatogr. B, 769, 169-176.
    View publication on PubMed
Search for more literature for 1.3.1.1

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5,6-dihydrouracil + NAD+ Homo sapiens
-
 uracil + NADH + H+
-
 r
5-fluorouracil + NAD+ Homo sapiens rate-limiting step in the elimination of the chemotherapeutic drug fluoropyrimidine ? + NADH
-
 r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bone marrow
-
 Homo sapiens
-
intestine mucosa Homo sapiens
-
liver
-
 Homo sapiens
-
mononuclear cell peripheral blood Homo sapiens
-
mucosa intestine Homo sapiens
-
plasma
-
 Homo sapiens
-
spleen
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 development of a quantitative assay method, determination of substrate and product in plasma and urine samples, overview Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,6-dihydrouracil + NAD+
-
 Homo sapiens uracil + NADH + H+
-
 r
5-fluorouracil + NAD+
-
 Homo sapiens ? + NADH
-
 r
5-fluorouracil + NAD+ rate-limiting step in the elimination of the chemotherapeutic drug fluoropyrimidine Homo sapiens ? + NADH
-
 r

Synonyms

Synonyms Comment Organism
dihydropyrimidine dehydrogenase
-
 Homo sapiens
DPD
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Homo sapiens