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Literature summary for 1.21.99.4 extracted from

  • Ito, M.; Toyoda, N.; Nomura, E.; Takamura, Y.; Amino, N.; Iwasaka, T.; Takamatsu, J.; Miyauchi, A.; Nishikawa, M.
    Type 1 and type 2 iodothyronine deiodinases in the thyroid gland of patients with 3,5,3'-triiodothyronine-predominant Graves' disease (2011), Eur. J. Endocrinol., 164, 95-100.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
thyroid gland
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-thyroxine + AH2
-
Homo sapiens 3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
?

Synonyms

Synonyms Comment Organism
DIO1
-
Homo sapiens
DIO2
-
Homo sapiens
type 1 iodothyronine deiodinase
-
Homo sapiens
type 2 iodothyronine deiodinase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
dithioerythritol
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens there is no significant difference between the thyroidal type 2 iodothyronine deiodinase mRNA level in patients with with 3,5,3'-triiodothyronine-predominant Graves' disease and that in patients with common type-Graves' disease additional information
Homo sapiens thyroidal type 1 iodothyronine deiodinase mRNA level and activity in patients with 3,5,3'-triiodothyronine-predominant Graves' disease is significantly higher than that in patients with common type-Graves' disease up