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Literature summary for 1.21.99.4 extracted from

  • Meyer, E.L.; Goemann, I.M.; Dora, J.M.; Wagner, M.S.; Maia, A.L.
    Type 2 iodothyronine deiodinase is highly expressed in medullary thyroid carcinoma (2008), Mol. Cell. Endocrinol., 289, 16-22.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
(Bu)2cAMP significantly stimulates deiodinating activity in TT cells Homo sapiens
DEX
-
Homo sapiens
forskolin significantly stimulates deiodinating activity in TT cells Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0000023
-
L-thyroxine neoplastic tissue, apparent Km Homo sapiens
0.0000026
-
L-thyroxine TT cell, apparent Km Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-thyroxine + AH2 Homo sapiens
-
3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
medullary thyroid carcinoma cell
-
Homo sapiens
-
medullary thyroid carcinoma cell line
-
Homo sapiens
-
TT cell
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.00000000041
-
medullary thyroid carcinoma Homo sapiens
0.00000000043
-
normal thyroid tissue Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-thyroxine + AH2
-
Homo sapiens 3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
?

Synonyms

Synonyms Comment Organism
type 2 iodothyronine deiodinase
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
activity assay Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.9
-
activity assay Homo sapiens

Expression

Organism Comment Expression
Homo sapiens 3,5,3'-triiodothyronine decreases mRNA levels in TT cell, addition of thyroxine or 3,3',5'-triiodothyronine decreases the deiodinating activity down