Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.21.99.3 extracted from

  • Akiyama, S.; Ogiwara, T.; Aoki, T.; Tsunekawa, K.; Araki, O.; Murakami, M.
    Glucagon-like peptide-1 stimulates type 3 iodothyronine deiodinase expression in a mouse insulinoma cell line (2014), Life Sci., 115, 22-28.
    View publication on PubMed
Search for more literature for 1.21.99.3

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3,3',5'-triiodo-L-thyronine + iodide + acceptor + H+ Mus musculus
-
 L-thyroxine + reduced acceptor
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q91ZI8
-
-

Source Tissue

Source Tissue Comment Organism Textmining
insulinoma cell
-
 Mus musculus
-
MIN-6 cell
-
 Mus musculus
-
pancreatic beta cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3,3',5'-triiodo-L-thyronine + iodide + acceptor + H+
-
 Mus musculus L-thyroxine + reduced acceptor
-
 ?

Synonyms

Synonyms Comment Organism
type 3 iodothyronine deiodinase
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus glucagon-like peptide-1 stimulates type 3 iodothyronine deiodinase expression in Min6 cells in a dose-dependent manner through a GLP-1 receptor-cAMP-PKA-medicated mechanism, and this effect is inhibited by the protein kinase A inhibitor H-89. Exendin-4, a GLP-1 receptor agonist, and forskolin also stimulates type 3 deiodinase expression in MIN6 cells. A cAMP pathway mediates the pretranslational regulation of D3 expression in MIN6 cells up

General Information

General Information Comment Organism
metabolism physiological role of thyroid hormones in the regulation of insulin secretion, overview. type 3 iodothyronine deiodinase-mediated thyroid hormone inactivation is thought to participate in glucose-stimulated insulin secretion from beta cellsA cAMP pathway mediates the pretranslational regulation of D3 expression in MIN6 cells Mus musculus
physiological function type 3 iodothyronine deiodinase (D3) converts thyroxine (T4) and 3,5,3'-triiodothyronine (T3) to3,3',5-triiodothyronine (rT3) and 3,3'-diiodothyronine (T2), respectively, inactivating thyroid hormones in a cell-specific fashion Mus musculus