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Literature summary for 1.21.99.3 extracted from

  • Boelen, A.; Kwakkel, J.; Wieland, C.W.; St Germain, D.L.; Fliers, E.; Hernandez, A.
    Impaired bacterial clearance in type 3 deiodinase-deficient mice infected with Streptococcus pneumoniae (2009), Endocrinology, 150, 1984-1990.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information by activation of type 3 deiodinase during illness reduction of thyroid hormone levels Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
triiodothyronine
-
Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
wild-type and type 3 deiodinase knockout mice, infected with Streptococcus pneumoniae
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3,3',5'-triido-L-thyronine + iodide + A + H+ assay at pH 7.2 Mus musculus L-thyroxine + AH2
-
?

Synonyms

Synonyms Comment Organism
type 3 deiodinase
-
Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
assay at Mus musculus

General Information

General Information Comment Organism
physiological function role in innate immune response, reduction of thyroid hormone levels during illness, protective role in defense against acute bacterial infection, probably by reinforcement of microbial killing capacity of neutrophils Mus musculus