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Literature summary for 1.21.99.3 extracted from

  • Ramauge, M.; Pallud, S.; Esfandiari, A.; Gavaret, J.; Lennon, A.; Pierre, M.; Courtin, F.
    Evidence that type III iodothyronine deiodinase in rat astrocyte is a selenoprotein (1996), Endocrinology, 137, 3021-3025.
    View publication on PubMed
Search for more literature for 1.21.99.3

Activating Compound

Activating Compound Comment Organism Structure
12-O-tetradecanoylphorbol-13-acetate induction of isozyme type III from brain astrocytes Rattus norvegicus
acidic fibroblast growth factor slight increase of 3,3',5,5'-tetraiodo-L-thyronine 5-deiodinase activity by isozyme type III Rattus norvegicus
acidic fibroblast growth factor induction of isozyme type III 3,3',5-triiodo-L-thyronine 5-deiodinase activity from brain astrocytes, 6fold higher in Se-repleted than in depleted cells Rattus norvegicus
actinomycin D induction of isozyme type III from brain astrocytes Rattus norvegicus
cAMP induction of isozyme type III from brain astrocytes Rattus norvegicus
retinoic acid induction of isozyme type III from brain astrocytes Rattus norvegicus
Se2+ required, depletion reversibly reduces the activity of isozyme type III by 3-10fold in cultured brain astrocytes Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
aurothioglucose no inhibition, isozyme type III Rattus norvegicus
cycloheximide isozyme type III, slight decrease of activity in vivo Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.000001
-
 3,3',5-triiodo-L-thyronine pH 7.4, 37°C Rattus norvegicus
0.000001
-
 3,3',5-triiodo-L-thyronine not influenced by selenium-deficiency Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 selenoprotein
-
Rattus norvegicus
-
 isozyme type III
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocyte cell culture Rattus norvegicus
-
astrocyte isozyme type III Rattus norvegicus
-
cell culture astrocytes Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3,3',5-triiodo-L-thyronine + AH2 isozyme type III Rattus norvegicus 3,3'-diiodo-L-thyronine + iodide + A + H+
-
 ?
L-thyroxine + AH2 preferred substrate Rattus norvegicus 3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
 ?
L-thyroxine + AH2 isozyme type III Rattus norvegicus 3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
 ?
L-thyroxine + AH2 5-deiodinase activity Rattus norvegicus 3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Rattus norvegicus