Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3',5'-diiodothyronine | comparison with 5'-deiodinase EC 1.97.1.10 | Rattus norvegicus | |
3,3',5'-triiodothyronine | comparison with 5'-deiodinase EC 1.97.1.10 | Rattus norvegicus | |
3,5,3'-triiodo-5'-nitrothyronine | comparison with 5'-deiodinase EC 1.97.1.10 | Rattus norvegicus | |
3,5,5'-triiodo-2'-methylthyronine | comparison with 5'-deiodinase EC 1.97.1.10 | Rattus norvegicus | |
3,5-diiodo-2'-hydroxythyronine | comparison with 5'-deiodinase EC 1.97.1.10 | Rattus norvegicus | |
3,5-diiodo-3',5'-dinitrothyronine | comparison with 5'-deiodinase EC 1.97.1.10 | Rattus norvegicus | |
3,5-diiodo-3'-hydroxythyronine | comparison with 5'-deiodinase EC 1.97.1.10 | Rattus norvegicus | |
3,5-diiodo-4'-amino-3',5'-dimethylthyronine | comparison with 5'-deiodinase EC 1.97.1.10 | Rattus norvegicus | |
N-acetyl-3,5,3'-triiodo-5'-nitrothyronine | comparison with 5'-deiodinase EC 1.97.1.10 | Rattus norvegicus | |
N-acetyl-3,5-diiodo-3',5'-dinitrothyronine | comparison with 5'-deiodinase EC 1.97.1.10 | Rattus norvegicus | |
N-acetyl-3,5-diiodo-3'-bromo-5'-nitrothyronine | comparison with 5'-deiodinase EC 1.97.1.10 | Rattus norvegicus | |
Tetraiodothyroacetic acid | comparison with 5'-deiodinase EC 1.97.1.10 | Rattus norvegicus | |
[4-(4-hydroxy-3,5-diiodophenoxy)phenyl]acetic acid | comparison with 5'-deiodinase EC 1.97.1.10 | Rattus norvegicus | |
[4-(4-hydroxy-3,5-dinitrophenoxy)-3,5-diiodophenyl]acetic acid | comparison with 5'-deiodinase EC 1.97.1.10 | Rattus norvegicus | |
[4-(4-hydroxy-3-iodo-5-nitrophenoxy)-3,5-diiodophenyl]acetic acid | comparison with 5'-deiodinase EC 1.97.1.10 | Rattus norvegicus | |
[4-(4-hydroxy-3-iodo-5-nitrophenoxy)phenyl]acetic acid | comparison with 5'-deiodinase EC 1.97.1.10 | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Rattus norvegicus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-thyroxine + AH2 | Rattus norvegicus | - |
3,3',5'-triiodo-L-thyronine + iodide + A + H+ | - |
? | |
additional information | Rattus norvegicus | L-hormone analogues are preferentially deiodinated via the T4-5'-deiodination pathway, whereas D-analogues produce products via the T4-5-deiodination pathway | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-thyroxine + AH2 | - |
Rattus norvegicus | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | - |
? | |
additional information | L-hormone analogues are preferentially deiodinated via the T4-5'-deiodination pathway, whereas D-analogues produce products via the T4-5-deiodination pathway | Rattus norvegicus | ? | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0003 | - |
pH 7.4, 37°C | Rattus norvegicus | [4-(4-hydroxy-3,5-diiodophenoxy)phenyl]acetic acid | |
0.0008 | - |
pH 7.4, 37°C | Rattus norvegicus | [4-(4-hydroxy-3-iodo-5-nitrophenoxy)-3,5-diiodophenyl]acetate | |
0.001 | - |
pH 7.4, 37°C | Rattus norvegicus | N-acetyl-3,5,3'-triiodo-5'-nitrothyronine | |
0.001 | - |
pH 7.4, 37°C | Rattus norvegicus | [4-(4-hydroxy-3,5-dinitrophenoxy)-3,5-diiodophenyl]acetic acid | |
0.001 | - |
pH 7.4, 37°C | Rattus norvegicus | [4-(4-hydroxy-3-iodo-5-nitrophenoxy)phenyl]acetic acid | |
0.002 | - |
pH 7.4, 37°C | Rattus norvegicus | Tetraiodothyroacetic acid | |
0.0025 | - |
pH 7.4, 37°C | Rattus norvegicus | 3',5'-diiodothyronine | |
0.003 | - |
pH 7.4, 37°C | Rattus norvegicus | N-acetyl-3,5-diiodo-3'-bromo-5'-nitrothyronine | |
0.005 | - |
pH 7.4, 37°C | Rattus norvegicus | 3,5,5'-triiodo-2'-methylthyronine | |
0.006 | - |
pH 7.4, 37°C | Rattus norvegicus | 3,5,3'-triiodo-5'-nitrothyronine | |
0.006 | - |
pH 7.4, 37°C | Rattus norvegicus | N-acetyl-3,5-diiodo-3',5'-dinitrothyronine | |
0.01 | - |
pH 7.4, 37°C | Rattus norvegicus | 3,5-diiodo-3',5'-dinitrothyronine | |
0.014 | - |
pH 7.4, 37°C | Rattus norvegicus | 3,5-diiodo-3'-hydroxythyronine | |
0.017 | - |
pH 7.4, 37°C | Rattus norvegicus | 3,5-diiodo-4'-amino-3',5'-dimethylthyronine |