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Literature summary for 1.21.3.7 extracted from
- First direct evidence for the mechanism of DELTA1-tetrahydrocannabinolic acid biosynthesis (1995), J. Am. Chem. Soc., 117, 9766-9767.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Fe3+ | 91% residual activity at 2 mM Fe3+ | Cannabis sativa |  |
| Hg2+ | strong inhibitor, 4% residual activity at 2 mM Hg2+ | Cannabis sativa | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.134 | - |
cannabigerolate | at pH 6.0, temperature not specified in the publication | Cannabis sativa | |
| 0.254 | - |
cannabinerolate | at pH 6.0, temperature not specified in the publication | Cannabis sativa | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| additional information | the enzyme is not influenced by Ca2+, Mg2+ and Mn2+ | Cannabis sativa |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 74000 | - |
gel filtration | Cannabis sativa |
| 75000 | - |
1 * 75000, SDS-PAGE | Cannabis sativa |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cannabis sativa | - |
Mexican strain | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| diethylaminoethyl-cellulose column chromatography, phenyl Sepharose CL-4B column chromatography, and hydroxylapatite column chromatography | Cannabis sativa |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| leaf bud | - |
Cannabis sativa | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cannabigerolate + O2 | best substrate | Cannabis sativa | DELTA9-tetrahydrocannabinolate + H2O2 | - |
? | |
| cannabinerolate + O2 | - |
Cannabis sativa | DELTA9-tetrahydrocannabinolate + H2O2 | - |
? | |
| additional information | cannabigerol and cannabinero are no substrates | Cannabis sativa | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 75000, SDS-PAGE | Cannabis sativa |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DELA1-THCA synthase | - |
Cannabis sativa |
| DELTA1-tetrahydrocannabinolic acid synthase | - |
Cannabis sativa |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5.5 | 6 | - |
Cannabis sativa |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| additional information | NAD+, NADP+, FAD, and FMN do not stimulate the enzyme activity | Cannabis sativa |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Cannabis sativa | isoelectric focusing | - |
6.4 |
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