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Literature summary for 1.2.7.4 extracted from

  • Ragsdale, S.W.; Wood, H.G.
    Acetate biosynthesis by acetogenic bacteria. Evidence that carbon monoxide dehydrogenase is the condensing enzyme that catalyzes the final steps of the synthesis (1985), J. Biol. Chem., 260, 3970-3977.
    View publication on PubMed
Search for more literature for 1.2.7.4

Inhibitors

Inhibitors Comment Organism Structure
5,5'-dithiobis (2-nitrobenzoate)
-
 Moorella thermoacetica
Mersalyl acid
-
 Moorella thermoacetica
methyl iodide
-
 Moorella thermoacetica
additional information phenylglyoxal, methylglyoxal, butanedione, mersalyl acid, methyl iodide, 5,5'-dithiobis (2-nitrobenzoate) and sodium dithionite inhibits the exchange reaction between CO and acetyl-CoA Moorella thermoacetica

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CO + H2O + electron acceptor Moorella thermoacetica key role of the enzyme in the synthesis of acetyl-CoA ?
-
 ?
CO + H2O + oxidized ferredoxin Moorella thermoacetica acetate biosynthesis pathway, catalyzes an exchange reaction between CO and the carbonyl group of acetyl-CoA CO2 + reduced ferredoxin
-
 ?

Organism

Organism UniProt Comment Textmining
Moorella thermoacetica
-
-
-
Moorella thermoacetica
-
 formerly Clostridium thermoaceticum
-

Purification (Commentary)

Purification (Comment) Organism
-
 Moorella thermoacetica

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CO + H2O + electron acceptor key role of the enzyme in the synthesis of acetyl-CoA Moorella thermoacetica ?
-
 ?
CO + H2O + methyl viologen catalyzes at a low rate an exchange between CO2 and the carbonyl group of acetyl-CoA Moorella thermoacetica CO2 + reduced methyl viologen
-
 ?
CO + H2O + methyl viologen catalyzes an exchange reaction between CO and the carbonyl group of acetyl-CoA Moorella thermoacetica CO2 + reduced methyl viologen
-
 ?
CO + H2O + oxidized ferredoxin
-
 Moorella thermoacetica CO2 + reduced ferredoxin
-
 ?
CO + H2O + oxidized ferredoxin acetate biosynthesis pathway, catalyzes an exchange reaction between CO and the carbonyl group of acetyl-CoA Moorella thermoacetica CO2 + reduced ferredoxin
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
additional information
-
 additional information pH 5.3, 50°C, activity of CO oxidation to CO2, ferredoxin II as electron carrier, turnover number is approximately 780 mol/mol of CO dehydrogenase Moorella thermoacetica
1.17
-
 CO turnover mumber for CO/CO2 exchange reaction Moorella thermoacetica
13
-
 CO CO oxidation, 50°C, pH 5.3, electron acceptor ferredoxin II Moorella thermoacetica

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.3
-
-
 Moorella thermoacetica