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Literature summary for 1.2.4.2 extracted from

  • Graf, A.; Kabysheva, M.; Klimuk, E.; Trofimova, L.; Dunaeva, T.; ZĂ1/4ndorf, G.; Kahlert, S.; Reiser, G.; Storozhevykh, T.; Pinelis, V.; Sokolova, N.; Bunik, V.
    Role of 2-oxoglutarate dehydrogenase in brain pathologies involving glutamate neurotoxicity (2009), J. Mol. Catal. B, 61, 80-87.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
succinyl phosphonate OGDHC inhibitor competitive to 2-oxoglutarate, 0.005 mM succinyl phosphonate protects OGDHC from catalysis-induced inactivation Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Rattus norvegicus 5739
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial purification Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain cortex
-
Rattus norvegicus
-
cerebellum
-
Rattus norvegicus
-
hippocampus
-
Rattus norvegicus
-
neuron hippocampal neuron Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
-
Rattus norvegicus [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
-
?

Synonyms

Synonyms Comment Organism
2-oxoglutarate dehydrogenase complex
-
Rattus norvegicus
OGDHC
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Rattus norvegicus
thiamine diphosphate
-
Rattus norvegicus