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Literature summary for 1.2.4.2 extracted from

  • Schulze, E.; Westphal, A.H.; Hanemaaijer, R.; de Kok A.
    The 2-oxoglutarate dehydrogenase complex from Azotobacter vinelandii. 1. Molecular cloning and sequence analysis of the gene encoding the 2-oxoglutarate dehydrogenase component (1990), Eur. J. Biochem., 187, 229-234.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
2-oxoglutarate dehydrogenase component E1o of the 2-oxoglutarate dehydrogenase complex Azotobacter vinelandii

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
103000
-
x * 103000, 2-oxoglutarate dehydrogenase subunit, SDS-PAGE Azotobacter vinelandii
105687
-
x * 105687, 2-oxoglutarate dehydrogenase subunit, calculation from nucleotide sequence Azotobacter vinelandii

Organism

Organism UniProt Comment Textmining
Azotobacter vinelandii
-
-
-

Reaction

Reaction Comment Organism Reaction ID
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 2-oxoglutarate dehydrogenase complex consists of 3 enzymes: E1 (alpha-ketoglutarate dehydrogenase, EC 1.2.4.2), E2 (dihydrolipoyl transsuccinylase, EC 2.3.1.61), E3 (dihydrolipoyl dehydrogenase, EC 1.8.1.4) Azotobacter vinelandii
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 the enzyme complex catalyzes the reaction : 2-oxoglutarate + CoA + NAD+--> succinyl-CoA + CO2 + NADH, the following partial reactions are catalyzed: 1. HOOC(CH2)2COCOOH + (thiamine diphosphate)-E1--> (HOOC(CH2)2 CHOH-thiamine-diphosphate)-E1 + CO2, 2. (HOOC(CH2)2CH OH-thiamine-diphosphate)-E1 + (LipS2)-E2--> (HOOC(CH)2 CO-(SLipSH))-E2 + (thiamine-diphosphate)-E1, 3. (HOOC(CH2)2CO-(SLipSH))-E2 + HSCoA--> (Lip(SH)2)-E2 + HOOC(CH2)2CO-SCoA, 4. (Lip(SH)2)-E2 + E3-FAD--> (LipS2)-E2 + reduced E3-FAD, 5. reduced E3-FAD + NAD+--> E3-FAD + NADH Azotobacter vinelandii

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-oxoglutarate + lipoamide
-
Azotobacter vinelandii S-succinyldihydrolipoamide + CO2
-
?

Subunits

Subunits Comment Organism
? x * 105687, 2-oxoglutarate dehydrogenase subunit, calculation from nucleotide sequence Azotobacter vinelandii
? x * 103000, 2-oxoglutarate dehydrogenase subunit, SDS-PAGE Azotobacter vinelandii