Protein Variants | Comment | Organism |
---|---|---|
E410K | CC-bond formation is dramatically slowed down (10-fold compared with E1ec) in E401K, the loop dynamics apparently greatly influences covalent addition of substrate to the enzyme-bound thiamine diphosphate | Escherichia coli |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
100000 | - |
2 * 100000, SDS-PAGE | Escherichia coli |
200000 | - |
SDS-PAGE | Escherichia coli |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
pyruvate + CoA + oxidized 2,6-dichlorophenolindophenol | - |
Escherichia coli | acetyl-CoA + CO2 + reduced 2,6-dichlorophenolindophenol | - |
? |
Subunits | Comment | Organism |
---|---|---|
homodimer | 2 * 100000, SDS-PAGE | Escherichia coli |
Synonyms | Comment | Organism |
---|---|---|
E1 component of pyruvate dehydrogenase multienzyme complex | - |
Escherichia coli |
E1ec | - |
Escherichia coli |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
thiamine diphosphate | dependent | Escherichia coli |