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Literature summary for 1.2.4.1 extracted from
- Theoretical calculation of the binding free energies for pyruvate dehydrogenase E1 binding with ligands (2007), Bioorg. Med. Chem. Lett., 17, 5186-5190.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Methylacetylphosphonate | - |
Escherichia coli |  |
| thiamine thiazolone diphosphate | - |
Escherichia coli | |
| thiamine thiothiazolone diphosphate | - |
Escherichia coli | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | activates | Escherichia coli | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pyruvate + CoA + NAD+ | - |
Escherichia coli | acetyl-CoA + CO2 + NADH | - |
? | |
| pyruvate + lipoamide | - |
Escherichia coli | S-acetyldihydrolipoamide + CO2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PDHc E1 | - |
Escherichia coli |
| pyruvate dehydrogenase multienzyme complex E1 | - |
Escherichia coli |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Escherichia coli | |
| thiamine diphosphate | - |
Escherichia coli | |
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Release 2023.1 (January 2023)
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