Cloned (Comment) | Organism |
---|---|
expression in HEK 293 cells | Homo sapiens |
expression in HEK 293 cells | Mus musculus |
expression using baculoviral system | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | no product inhibition by hexadecanol; no product inhibition by hexadecanol | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Mus musculus | 16020 | - |
peroxisome | - |
Mus musculus | 5777 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8WVX9 | FAR1 | - |
Mus musculus | Q7TNT2 | - |
- |
Mus musculus | Q922J9 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
epididymis | - |
Mus musculus | - |
eyelid | - |
Mus musculus | - |
eyelid | most abundant in | Mus musculus | - |
eyelid | and skin, tissues with highest expression | Mus musculus | - |
heart | - |
Mus musculus | - |
J-774 cell | - |
Mus musculus | - |
kidney | - |
Mus musculus | - |
lung | - |
Mus musculus | - |
additional information | isoform FAR2 is present at lower levels than isoform FAR1 | Mus musculus | - |
additional information | present in all tissues and cell lines examined | Mus musculus | - |
muscle | - |
Mus musculus | - |
ovary | - |
Mus musculus | - |
peritoneal macrophage | - |
Mus musculus | - |
preputial gland | tissue with highest mRNA level | Mus musculus | - |
sebaceous gland | highest expression in preputial gland, a specialised sebaceous gland | Mus musculus | - |
seminal vesicle | - |
Mus musculus | - |
skin | - |
Mus musculus | - |
skin | most abundant in | Mus musculus | - |
skin | and eyelid, tissues with highest expression | Mus musculus | - |
small intestine | - |
Mus musculus | - |
small intestine | most abundant in | Mus musculus | - |
spleen | - |
Mus musculus | - |
testis | - |
Mus musculus | - |
thymus | - |
Mus musculus | - |
white adipose tissue | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
arachidonoyl-CoA + NADPH | low activity | Mus musculus | cis-5,8,11,14-eicosatetraenal + NADP+ + CoA | - |
? | |
homo-gamma-linolenoyl-CoA + NADPH | low activity | Mus musculus | ? + NADP+ + CoA | - |
? | |
linoleoyl-CoA + NADPH | - |
Mus musculus | cis-9,12-octadecadienal + NADP+ + CoA | - |
? | |
additional information | no activity with oleoyl-CoA, linoleoyl-CoA, homo-gamma-linoleoyl-CoA or arachidonoyl-CoA | Mus musculus | ? | - |
? | |
additional information | isoform FAR1 prefers C16, C18, C18:1, and C18:2 fatty acids and is less active against other lipids | Mus musculus | ? | - |
? | |
additional information | isoform FAR2 prefers saturated C16 and C18 fatty acids | Mus musculus | ? | - |
? | |
oleoyl-CoA + NADPH | - |
Mus musculus | cis-9-octadecenal + NADP+ + CoA | - |
? | |
palmitoyl-CoA + 2 NADPH + 2 H+ | - |
Mus musculus | hexadecanol + 2 NADP+ + coenzyme A | - |
? | |
palmitoyl-CoA + NADPH | - |
Mus musculus | hexadecanal + NADP+ + CoA | - |
? | |
stearoyl-CoA + NADPH | - |
Mus musculus | octadecanal + NADP+ + CoA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
FAR1 | - |
Homo sapiens |
FAR1 | - |
Mus musculus |
FAR2 | - |
Mus musculus |
fatty acyl-Coenzyme A reductase | - |
Homo sapiens |
fatty acyl-Coenzyme A reductase | - |
Mus musculus |
male sterility domain-containing protein 1 | - |
Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | 8 | reaction with palmitoyl-CoA | Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
additional information | no cofactor: NADH | Mus musculus | |
NADPH | - |
Homo sapiens | |
NADPH | - |
Mus musculus | |
NADPH | no activity with NADH | Mus musculus | |
NADPH | specific for NADPH | Mus musculus |