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Literature summary for 1.2.1.84 extracted from

  • Cheng, J.B.; Russell, D.W.
    Mammalian wax biosynthesis. I. Identification of two fatty acyl-Coenzyme A reductases with different substrate specificities and tissue distributions (2004), J. Biol. Chem., 279, 37789-37797.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in HEK 293 cells Homo sapiens
expression in HEK 293 cells Mus musculus
expression using baculoviral system Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information no product inhibition by hexadecanol; no product inhibition by hexadecanol Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Mus musculus 16020
-
peroxisome
-
Mus musculus 5777
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8WVX9 FAR1
-
Mus musculus Q7TNT2
-
-
Mus musculus Q922J9
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Mus musculus
-
epididymis
-
Mus musculus
-
eyelid
-
Mus musculus
-
eyelid most abundant in Mus musculus
-
eyelid and skin, tissues with highest expression Mus musculus
-
heart
-
Mus musculus
-
J-774 cell
-
Mus musculus
-
kidney
-
Mus musculus
-
lung
-
Mus musculus
-
additional information isoform FAR2 is present at lower levels than isoform FAR1 Mus musculus
-
additional information present in all tissues and cell lines examined Mus musculus
-
muscle
-
Mus musculus
-
ovary
-
Mus musculus
-
peritoneal macrophage
-
Mus musculus
-
preputial gland tissue with highest mRNA level Mus musculus
-
sebaceous gland highest expression in preputial gland, a specialised sebaceous gland Mus musculus
-
seminal vesicle
-
Mus musculus
-
skin
-
Mus musculus
-
skin most abundant in Mus musculus
-
skin and eyelid, tissues with highest expression Mus musculus
-
small intestine
-
Mus musculus
-
small intestine most abundant in Mus musculus
-
spleen
-
Mus musculus
-
testis
-
Mus musculus
-
thymus
-
Mus musculus
-
white adipose tissue
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
arachidonoyl-CoA + NADPH low activity Mus musculus cis-5,8,11,14-eicosatetraenal + NADP+ + CoA
-
?
homo-gamma-linolenoyl-CoA + NADPH low activity Mus musculus ? + NADP+ + CoA
-
?
linoleoyl-CoA + NADPH
-
Mus musculus cis-9,12-octadecadienal + NADP+ + CoA
-
?
additional information no activity with oleoyl-CoA, linoleoyl-CoA, homo-gamma-linoleoyl-CoA or arachidonoyl-CoA Mus musculus ?
-
?
additional information isoform FAR1 prefers C16, C18, C18:1, and C18:2 fatty acids and is less active against other lipids Mus musculus ?
-
?
additional information isoform FAR2 prefers saturated C16 and C18 fatty acids Mus musculus ?
-
?
oleoyl-CoA + NADPH
-
Mus musculus cis-9-octadecenal + NADP+ + CoA
-
?
palmitoyl-CoA + 2 NADPH + 2 H+
-
Mus musculus hexadecanol + 2 NADP+ + coenzyme A
-
?
palmitoyl-CoA + NADPH
-
Mus musculus hexadecanal + NADP+ + CoA
-
?
stearoyl-CoA + NADPH
-
Mus musculus octadecanal + NADP+ + CoA
-
?

Synonyms

Synonyms Comment Organism
FAR1
-
Homo sapiens
FAR1
-
Mus musculus
FAR2
-
Mus musculus
fatty acyl-Coenzyme A reductase
-
Homo sapiens
fatty acyl-Coenzyme A reductase
-
Mus musculus
male sterility domain-containing protein 1
-
Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7 8 reaction with palmitoyl-CoA Mus musculus

Cofactor

Cofactor Comment Organism Structure
additional information no cofactor: NADH Mus musculus
NADPH
-
Homo sapiens
NADPH
-
Mus musculus
NADPH no activity with NADH Mus musculus
NADPH specific for NADPH Mus musculus