Literature summary for 1.2.1.8 extracted from

Zarate-Romero, A.; Murillo-Melo, D.S.; Mujica-Jimenez, C.; Montiel, C.; Munoz-Clares, R.A.
Reversible, partial inactivation of plant betaine aldehyde dehydrogenase by betaine aldehyde: mechanism and possible physiological implications (2016), Biochem. J., 473, 873-885.

Search for more literature for 1.2.1.8

Protein Variants

Protein Variants	Comment	Organism
A441C	the mutant demonstrates reduced substrate inhibition by betaine aldehyde	Spinacia oleracea
A441I	the mutant demonstrates reduced substrate inhibition by betaine aldehyde	Spinacia oleracea
C450S	the mutant is not inhibited by betaine aldehyde	Spinacia oleracea

Inhibitors

Inhibitors	Comment	Organism	Structure
Betaine aldehyde	the enzyme is reversibly and partially inactivated by betaine aldehyde in the absence of NAD+ in a time- and concentration-dependent mode	Spinacia oleracea

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
betaine aldehyde + NAD+ + H2O	Spinacia oleracea	-	betaine + NADH + 2 H+	-	ir

Organism

Organism	UniProt	Comment	Textmining
Spinacia oleracea	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
betaine aldehyde + NAD+ + H2O	-	Spinacia oleracea	betaine + NADH + 2 H+	-	ir

Synonyms

Synonyms	Comment	Organism
ALDH10	-	Spinacia oleracea
BADH	-	Spinacia oleracea

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Spinacia oleracea

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Release 2023.1 (January 2023)