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Literature summary for 1.2.1.8 extracted from
- Kinetic study of porcine kidney betaine aldehyde dehydrogenase (2000), Biochem. Biophys. Res. Commun., 269, 596-603.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| AMP | competitive with respect to NAD+ and mixed with betaine aldehyde | Sus scrofa |  |
| Betaine aldehyde | substrate inhibition | Sus scrofa | |
| choline | competitive against betaine aldehyde and uncompetitive with respect to NAD+ | Sus scrofa | |
| NADH | mixed inhibited against NAD+ and betaine aldehyde | Sus scrofa | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0445 | - |
NAD+ | - |
Sus scrofa | |
| 0.1455 | - |
Betaine aldehyde | - |
Sus scrofa | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sus scrofa | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| betaine aldehyde + NAD+ + H2O = betaine + NADH + 2 H+ | iso-ordered bi-bi steady state mechanism | Sus scrofa |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Sus scrofa | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| betaine aldehyde + NAD+ + H2O | - |
Sus scrofa | betaine + NADH | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | - |
Sus scrofa |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0111 | - |
choline | versus betaine aldehyde | Sus scrofa | |
| 0.8705 | - |
AMP | versus NAD+ | Sus scrofa | |
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