Activating Compound | Comment | Organism | Structure |
---|---|---|---|
L-2-Aminopropan-1-ol | activation of aldehyde oxidation | Ovis aries |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0045 | - |
NADP+ | - |
Ovis aries | |
0.21 | 0.83 | methylglyoxal | - |
Ovis aries | |
0.83 | - |
methylglyoxal | - |
Ovis aries | |
0.83 | - |
methylglyoxal | amine as activator in aldehyde oxidation | Ovis aries | |
0.83 | - |
methylglyoxal | in the presence of L-2-aminopropan-1-ol (Km 83 mM), at pH 9.3 and 25°C | Ovis aries |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
methylglyoxal + NADP+ + H2O | Ovis aries | - |
pyruvate + NADPH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Ovis aries | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Ovis aries | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.24 | - |
- |
Ovis aries |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-oxoaldehydes + NADP+ + H2O | enzyme from sheep or rat liver also active with NAD+, see also EC 1.2.1.23 | Ovis aries | 2-oxo acids + NADPH | - |
? | |
methylglyoxal + NADP+ + H2O | - |
Ovis aries | pyruvate + NADPH + H+ | - |
? | |
additional information | the presence of L-2-aminopropan-1-ol is necessary to activate the enzyme | Ovis aries | ? | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | enzyme from sheep or rat liver, see also EC 1.2.1.23 | Ovis aries | |
NADP+ | - |
Ovis aries |