Literature summary for 1.2.1.36 extracted from

Kurth, I.; Thompson, D.A.; Ruether, K.; Feathers, K.L.; Chrispell, J.D.; Schroth, J.; McHenry, C.L.; Schweizer, M.; Skosyrski, S.; Gal, A.; Huebner, C.A.
Targeted disruption of the murine retinal dehydrogenase gene Rdh12 does not limit visual cycle function (2007), Mol. Cell. Biol., 27, 1370-1379.

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Application

Application	Comment	Organism
medicine	activity of any one isoform is not rate limiting in the visual response	Mus musculus
additional information	similar localization of Rdh12 and RDH12 proteins in mouse and human photoreceptors, respectively, which may indicate an analogous physiological role of the enzymes in both species	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
into the pKO-V901 plasmid	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	Rdh12-/- mice are viable, develop normally, and can not be distinguished from heterozygous or wild-type littermates by mere observation. Rdh12 knockout mice exhibit grossly normal retinal histology at 10 months of age. Lipid peroxidation products and other measures of oxidative stress are not elevated in Rdh12-/- animals. Rdh12-/- and wild-type mice show approximately equivalent expression of the visual cycle genes Rdh5, Rpe65, Lrat, Cralbp, Crbp, Irbp, Rho, and Abcr. There is also no change in the expression of other Rdh isoforms expressed in photoreceptors, including Rdh8 (prRdh), Rdh11, Rdh13, Rdh14, and retSDR1	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Mus musculus	-	cross between 129/Sv and C57BL/6 mouse strains	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
retina	photoreceptor inner segments and the outer nuclear layer	Mus musculus	-
retina	photoreceptor inner segments and the outer nuclear layer	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
RDH12	-	Mus musculus

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Release 2023.1 (January 2023)