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Literature summary for 1.2.1.3 extracted from

  • Beretta, M.; Gruber, K.; Kollau, A.; Russwurm, M.; Koesling, D.; Goessler, W.; Keung, W.M.; Schmidt, K.; Mayer, B.
    Bioactivation of nitroglycerin by purified mitochondrial and cytosolic aldehyde dehydrogenases (2008), J. Biol. Chem., 283, 17873-17880.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
into the vector pT7.7 for expression in Escherichia coli BL21DE3 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Chloral hydrate
-
Homo sapiens
daidzin
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00033
-
acetaldehyde
-
Homo sapiens
0.2
-
acetaldehyde
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-
mitochondrion
-
Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
by p-hydroxyacetophenone affinity chromatography Homo sapiens
by p-hydroxyacetophenone affinity chromatography and gel filtration Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.00018
-
conversion of glycerol trinitrate to 1,3-glycerol dinitrate Homo sapiens
0.00066
-
conversion of glycerol trinitrate to 1,3-glycerol dinitrate Homo sapiens
0.003
-
conversion of glycerol trinitrate to 1,2-glycerol dinitrate Homo sapiens
0.009
-
conversion of glycerol trinitrate to 1,2-glycerol dinitrate Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetaldehyde + NAD+ + H2O activity assay Homo sapiens acetate + NADH + H+
-
?
glyceryl trinitrate + NADH + H+
-
Homo sapiens 1,2-glyceryl dinitrate + nitrite + NAD+
-
?
glyceryl trinitrate + NADH + H+
-
Homo sapiens 1,3-glyceryl dinitrate + nitrite + NAD+
-
?

Synonyms

Synonyms Comment Organism
aldehyde dehydrogenase 1
-
Homo sapiens
aldehyde dehydrogenase 2
-
Homo sapiens
ALDH1
-
Homo sapiens
ALDH2
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
activity assay Homo sapiens
37
-
incubation of ALDH with 14C-labeled nitroglycerin Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
incubation of ALDH with 14C-labeled nitroglycerin Homo sapiens
9
-
activity assay Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens