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Literature summary for 1.2.1.3 extracted from

  • Wierzchowski, J.; Pietrzak, M.; Szelag, M.; Wroczynski, P.
    Salivary aldehyde dehydrogenase-Reversible oxidation of the enzyme and its inhibition by caffeine, investigated using fluorimetric method (2008), Arch. Oral Biol., 53, 423-428.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Caffeine
-
Homo sapiens
theophylline
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00024
-
2-naphthalene carboxylate apparent Km value, diphosphate buffer, pH 8.1, cofactor NADH Homo sapiens
0.0012
-
NAD+ apparent Km value Homo sapiens
0.0017
-
6-dimethylamino-2-naphthaldehyde apparent Km value, pyrophosphate buffer, pH 8.1, cofactor NAD+ Homo sapiens
0.0079
-
6-dimethylamino-2-naphthaldehyde apparent Km value, phosphate buffer, pH 7.3, cofactor NAD+ Homo sapiens
0.0086
-
6-dimethylamino-2-naphthaldehyde apparent Km value, phosphate buffer, pH 6.2, cofactor NAD+ Homo sapiens
0.0114
-
6-dimethylamino-2-naphthaldehyde apparent Km value, phosphate buffer, pH 8.0, cofactor NAD+ Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens involved in detoxication of a variety of aldehydes of plant origin, as well as those formed during food processing, or applied as food additives ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
saliva
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-naphthaldehyde + NAD+ + H2O
-
Homo sapiens 2-naphthalene carboxylate + NADH + H+
-
?
6-dimethylamino-2-naphthaldehyde + NAD+ + H2O activity assay Homo sapiens 6-dimethylamino-2-naphthalene carboxylate + NADH + H+
-
?
6-methoxy-2-naphthaldehyde + NAD+ + H2O activity assay Homo sapiens 6-methoxy-2-naphthalene carboxylate + NADH + H+
-
?
additional information involved in detoxication of a variety of aldehydes of plant origin, as well as those formed during food processing, or applied as food additives Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
homodimer
-
Homo sapiens

Synonyms

Synonyms Comment Organism
aldehyde dehydrogenase
-
Homo sapiens
ALDH
-
Homo sapiens
ALDH3A1
-
Homo sapiens
benzaldehyde dehydrogenase
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
activity assay Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens
NADP+
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.5
-
Caffeine apparent Ki value Homo sapiens
7.3
-
theophylline apparent Ki value Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.5
-
-
Homo sapiens Caffeine
3.5
-
-
Homo sapiens theophylline