Protein Variants | Comment | Organism |
---|---|---|
A273S | the mutant shows enzyme activity reduction | Homo sapiens |
G36R | the slight activity reduction displayed by the G36R variant can be attributed to altered mitochondrial targeting, as the amino acid change lies within the mitochondrial leader sequence | Homo sapiens |
H180Y | the mutant shows enzyme activity reduction | Homo sapiens |
P182L | a significant activity reduction is observed for P182L | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | ALDH5A1 plays an important role as a gamma-aminobutyric acid catabolic enzyme and potentially as a detoxifying enzyme involved in aldehyde scavenging | ? | - |
? | |
succinate semialdehyde + NAD+ + H2O | Homo sapiens | - |
succinate + NADH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lymphoblast | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | ALDH5A1 plays an important role as a gamma-aminobutyric acid catabolic enzyme and potentially as a detoxifying enzyme involved in aldehyde scavenging | Homo sapiens | ? | - |
? | |
succinate semialdehyde + NAD+ + H2O | - |
Homo sapiens | succinate + NADH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
aldehyde dehydrogenase 5a1 | - |
Homo sapiens |
ALDH5A1 | - |
Homo sapiens |
SSADH | - |
Homo sapiens |
succinate semialdehyde dehydrogenase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens |