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Literature summary for 1.2.1.24 extracted from

  • Malaspina, P.; Picklo, M.J.; Jakobs, C.; Snead, O.C.; Gibson, K.M.
    Comparative genomics of aldehyde dehydrogenase 5a1 (succinate semialdehyde dehydrogenase) and accumulation of gamma-hydroxybutyrate associated with its deficiency (2009), Hum. Genomics, 3, 106-120.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
A273S the mutant shows enzyme activity reduction Homo sapiens
G36R the slight activity reduction displayed by the G36R variant can be attributed to altered mitochondrial targeting, as the amino acid change lies within the mitochondrial leader sequence Homo sapiens
H180Y the mutant shows enzyme activity reduction Homo sapiens
P182L a significant activity reduction is observed for P182L Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens ALDH5A1 plays an important role as a gamma-aminobutyric acid catabolic enzyme and potentially as a detoxifying enzyme involved in aldehyde scavenging ?
-
?
succinate semialdehyde + NAD+ + H2O Homo sapiens
-
succinate + NADH + H+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lymphoblast
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information ALDH5A1 plays an important role as a gamma-aminobutyric acid catabolic enzyme and potentially as a detoxifying enzyme involved in aldehyde scavenging Homo sapiens ?
-
?
succinate semialdehyde + NAD+ + H2O
-
Homo sapiens succinate + NADH + H+
-
?

Synonyms

Synonyms Comment Organism
aldehyde dehydrogenase 5a1
-
Homo sapiens
ALDH5A1
-
Homo sapiens
SSADH
-
Homo sapiens
succinate semialdehyde dehydrogenase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens