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Literature summary for 1.2.1.24 extracted from

  • Nguyen, E.; Picklo, M.J., Sr.
    Inhibition of succinic semialdehyde dehydrogenase activity by alkenal products of lipid peroxidation (2003), Biochim. Biophys. Acta, 1637, 107-112.
    View publication on PubMed
Search for more literature for 1.2.1.24

Inhibitors

Inhibitors Comment Organism Structure
4-hydroxy-trans-2-nonenal IC50: 0.11 mM Rattus norvegicus
acrolein irreversible, noncompetitive, IC50: 0.015 mM Rattus norvegicus
additional information no inhibition by 0.1 mM trans-2-hexenal and 0.1 mM crotonaldehyde Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0039
-
 succinate semialdehyde
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Rattus norvegicus 5739
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
succinate semialdehyde + NAD+ + H2O
-
 Rattus norvegicus succinate + NADH + H+
-
 ?

Synonyms

Synonyms Comment Organism
SSADH/ALDH5A1
-
 Rattus norvegicus
succinic semialdehyde dehydrogenase
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.015
-
 irreversible, noncompetitive, IC50: 0.015 mM Rattus norvegicus acrolein
0.11
-
 IC50: 0.11 mM Rattus norvegicus 4-hydroxy-trans-2-nonenal