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Literature summary for 1.2.1.24 extracted from
- Kinetic studies with rat-brain succinic-semialdehyde dehydrogenase (1981), Eur. J. Biochem., 117, 187-193.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4-hydroxybenzaldehyde | - |
Rattus norvegicus |  |
| acetaldehyde | above 1 mM | Rattus norvegicus | |
| AMP | 5'-AMP | Rattus norvegicus | |
| NADH | competitive with respect to NAD+; mixed with respect to succinate semialdehyde | Rattus norvegicus | |
| succinate semialdehyde | substrate inhibition, uncompetitive with respect to NAD+ | Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0025 | - |
NAD+ | - |
Rattus norvegicus | |
| 0.0027 | 0.0029 | succinate semialdehyde | - |
Rattus norvegicus | |
| 0.03 | - |
NAD+ | - |
Rattus norvegicus | |
| 0.05 | - |
3-acetylpyridine adenine dinucleotide | - |
Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| succinate semialdehyde + NAD+ + H2O = succinate + NADH + H+ | compulsory-order mechanism, NAD+ is the first substrate to bind to the enzyme and NADH is the last product to dissociate from it | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 2.12 | - |
- |
Rattus norvegicus |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -20°C, in presence of 10% v/v glycerol, stable for several months | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| succinate semialdehyde + 3-acetylpyridine adenine dinucleotide + H2O | - |
Rattus norvegicus | succinate + reduced 3-acetylpyridine adenine dinucleotide + H+ | - |
r | |
| succinate semialdehyde + NAD+ + H2O | - |
Rattus norvegicus | succinate + NADH | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.5 | - |
- |
Rattus norvegicus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 7 | 10 | pH 7.0: about 40% of maximal activity, pH 10.0: about 35% of maximal activity | Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| 3-acetylpyridine adenine dinucleotide | - |
Rattus norvegicus | |
| NAD+ | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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